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ProteomicsUse of the proteomics approach to study endometrial cancer.
Endometrial cancer (EC) is the second most frequent gynecological malignant tumor in postmenopausal women. Pathogenic mechanisms related to the onset and development of disease are still unknown. In this study, we aimed to characterize the EV proteome by combining Data-Independent Acquisition (DIA) ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058193 | Pride
Proteomics  mass spectrometry  extracellular vesicles 
ProteomicsSerum proteomic profiling uncovers dysregulated keratinization and immune-related pathways in hidradenitis suppurativa.
Hidradenitis suppurativa (HS) is an autoinflammatory keratinization disease affecting the pilosebaceous unit and hallmarked by a complex and multifactorial pathogenesis. In recent years, genetics and transcriptomics have been advancing in elucidating several crucial mechanisms underlying HS pathoge...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD074024 | Pride
Proteomics Keratinocyte Acne inversa Immunity Skin inflammation 
ProteomicsEnzyme–Metabolite Network Analysis of Endometrial Cancer-Derived Extracellular Vesicles Through Integrated Proteomics and Metabolomics.
: Endometrial cancer (EC) is the most common gynecological malignancy in high-income countries. Extracellular vesicles (EVs) are key mediators of intercellular communication and metabolic reprogramming, but their molecular cargo in EC remains poorly characterized. EVs were isolated from four EC cell...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD081461 | Pride
Enzyme–metabolite network analysis of endometrial cancer-derived extracellular vesicles through integrated proteomics and metabolomics. 
ProteomicsData-independent acquisition (DIA)-based proteomics for the identification of biomarkers in tissue washings of endometrial cancer
: Endometrial cancers (ECs), which are mainly adenocarcinomas arising from the uterine endometrium. In this work, we employed data-independent acquisition (DIA) mass spectrometry (MS)-based label-free quantification (LFQ-MS) proteomics to analyze the proteome of tissue washings collected from 25 con...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD069126 | Pride
Endometrial cancer  proteomics  mass spectrometry  tissue washings  biomarker 
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