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TranscriptomicsDeubiquitinase USP10 regulates Notch signaling in the endothelium
Notch signaling is critical for vascular morphogenesis by co-determining the sprouting behavior of endothelial cells. Here, we investigate the function of ubiquitin-specific peptidase 10 (USP10) in regulation of the turnover of the NOTCH1 intracellular domain. HUVEC were transfected with scrambled o...
ORGANISM(S): Homo sapiens 
2019-04-26 | E-MTAB-7774 | biostudies-arrayexpress
ProteomicsUSP10 knockout in human HCT116 cells
USP10 is an important factor in the progression of colorectal cancer, as inhibition or silencing of USP10 attenuates the aggressive phenotype. USP10 regulates sensitivity to the two widely used EGFR inhibitors gefitinib and osimertinib. Mechanistically, we show that USP10 mediates its effects via th...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052294 | Pride
Usp10 Colorectal cancer 
GenomicsRNA-seq from USP10 and TDP-43 overexpression and TDP-43 knockdown associated with or without USP10 overexpression in HeLa cells
RNA-seq from USP10 and TDP-43 overexpression and TDP-43 knockdown associated with or without USP10 overexpression in HeLa cells
PRJEB97173 | ENA
ProteomicsDeubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
ORGANISM(S): Homo 
2023-09-02 | PXD045063 |
TranscriptomicsRNA-seq from USP10 and TDP-43 overexpression and TDP-43 knockdown associated with or without USP10 overexpression in HeLa cells
We performed RNA-seq on HeLa cells to assess the shared transcriptomics changes between USP10 and TDP-43 overexpression, as well as to understand the effect of USP10 overexpression on TDP-43 loss-of-function targets.
ORGANISM(S): Homo sapiens 
2025-09-21 | E-MTAB-15564 | biostudies-arrayexpress
GenomicsUSP10 overexpression regulates transcriptomic changes in Ang II-stimulated HL-1 cardiomyocytes
USP10 overexpression regulates transcriptomic changes in Ang II-stimulated HL-1 cardiomyocytes
PRJNA1479010 | ENA
GenomicsEffect of USP10 knockout using CRISPR on gene expression in MCF7 breast cancer cells
Effect of USP10 knockout using CRISPR on gene expression in MCF7 breast cancer cells
PRJNA1291091 | ENA
TranscriptomicsEffect of USP10 knockout using CRISPR on gene expression in MCF7 breast cancer cells
Using a genome wide shRNa screen we identified the deubiqutinating enzyme USP10 as a potent regualtor of AKT activity. To validate our findings we performed RNA-Seq on MCF7 cells with or without USP10 depletion. In line with our previous observations we demonstrate that PI3k-AKT-mTOR pathway activat...
ORGANISM(S): Homo sapiens 
2025-07-28 | GSE302500 | GEO
TranscriptomicsUSP10 overexpression regulates transcriptomic changes in Ang II-stimulated HL-1 cardiomyocytes
This study investigated transcriptomic changes induced by USP10 overexpression in HL-1 mouse cardiomyocytes under angiotensin II (Ang II) stimulation. RNA sequencing was performed to compare USP10-overexpression and control groups, each with four biological replicates.
ORGANISM(S): Mus musculus 
2026-09-02 | GSE335617 | GEO
TranscriptomicsDevelopment of gene expression signatures for neonatal tissues of mice with Usp10 gene knockout
To further explore gene expression in neonatal mice with Usp10 gene knockout, we have employed whole genome microarray expression profiling as a discovery platform to identify the pathways or biological processes with the potential to explain the cause of postnatal death of Usp10 knockout mice. Kidn...
ORGANISM(S): Mus musculus 
2022-03-15 | GSE198574 | GEO
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