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ProteomicsImpact of miRNAs on the USSC proteome after XXL-differentiation
The contribution of microRNA-mediated posttranscriptional regulation on the final proteome in differentiating cells remains elusive. Here, we evaluated the impact of microRNAs (miRNAs) on the proteome of human umbilical cord blood-derived unrestricted somatic stem cells (USSC) during retinoic acid (...
ORGANISM(S): Homo sapiens (Human) 
2020-01-31 | PXD016915 | Pride
Neuronal differentiation Human Microrna Umbilical cord blood stem cells Retinoic acid Unrestricted somatic stem cells 
ProteomicsUSSC secretome - Characterization of regenerative phenotype of unrestricted somatic stem cells from human umbilical cord blood by functional secretome analysis
Stem cell transplantation is a promising therapeutic strategy to enhance axonal regeneration after spinal cord injury. Unrestricted somatic stem cells (USSC) isolated from human umbilical cord blood is an attractive stem cell population available at GMP grade without any ethical concerns. It has bee...
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD002241 | Pride
Stem cell Ussc Nerve regeneration Secretome Absolute quantification Spinal cord 
UnknownCharacterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.
Not available
S-EPMC4597141 | biostudies-literature
UnknownIncreased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1.
Not available
S-EPMC3649714 | biostudies-literature
UnknownMicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC.
Not available
S-EPMC3024412 | biostudies-literature
TranscriptomicsA Comparison of the Efficacy of Transplantation of Bone Marrow Derived Mesenchymal Stem Cells and Unrestricted Somatic Stem Cells on Outcome After Acute Myocardial Infarction
Unrestricted Somatic Stem Cells (USSC) are a cell population derived from umbilical cord blood. They have been shown to have greater plasticity than mesenchymal stem cells, and are being investigated as a therapeutic option for many disease states, including cardiovascular disease.

In this st...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-MEXP-3638 | biostudies-arrayexpress
TranscriptomicsCord blood multipotent stromal cells exploit a unique immune suppressive mechanism
Expression patterns of Dendritic cells co cultured with cord blood MSC were compared with cord blood MSC (USSC). Putative immune suppressive candidates were tested to explain this inhibition. We find that cord blood MSC themselves are hardly immunogenic as tested with allogeneic T-cells. Dendritic c...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-23366 | biostudies-arrayexpress
TranscriptomicsCord blood multipotent stromal cells exploit a unique immune suppressive mechanism
Expression patterns of Dendritic cells co cultured with cord blood MSC were compared with cord blood MSC (USSC). Putative immune suppressive candidates were tested to explain this inhibition. We find that cord blood MSC themselves are hardly immunogenic as tested with allogeneic T-cells. Dendritic c...
ORGANISM(S): Homo sapiens 
2010-08-03 | GSE23366 | GEO
UnknownMicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood.
Not available
S-EPMC3637629 | biostudies-literature
GenomicsFunctional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation [miRNA-Seq]
Functional analysis of transcriptome (mRNA and microRNA) and proteome formation during treatment of cord-blood derived stem cell lines (USSC) with retinoic acid-containing XXL-medium to estimate the impact of microRNAs on final proteome.
ORGANISM(S): Homo sapiens 
2020-03-09 | GSE144465 | GEO
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