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MetabolomicsSystemic Inflammation Induces Cholestasis via Upregulating a Short Variant of FTO to Remove the m6A Methylation in the 3’-UTR of Cyp7b1 mRNAs in liver
The cholestasis frequently occurs in patients with inflammatory processes. However, the mechanisms of inflammation in inducing cholestasis are still unclear. Here, by using lipopolysaccharide (LPS)-induced cholestasis mouse models, we found that most genes encoding enzymes responsible for bile acid ...
2025-11-07 | MTBLS10713 | MetaboLights
ProteomicsMS for RNA binding preteins in tapasin 3'UTR
Using affinity purification for the detection of RNA-binding proteins in tapasin 3'UTR
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045056 | Pride
Tapasin 3'utr 
TranscriptomicsCleavage Factor Im as a key regulator of 3’ UTR length
In eukaryotes, the 3' ends of RNA polymerase II-generated transcripts are made in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. By alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of t...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40137 | biostudies-arrayexpress
TranscriptomicsThe systematic shortening of 3’ UTRs has limited influence on the relative change in protein abundance in proliferating cells
Alternative polyadenylation is an important cellular mechanism that enables generation of mRNA isoforms that differ in their 3' untranslated regions (3' UTRs) and consequently in their susceptibility to miRNA and RNA binding protein mediated regulation. A dramatic change in polyadenylation site usa...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-54950 | biostudies-arrayexpress
ProteomicsPhototropin2 3'UTR overlaps with the AT5G58150 gene encoding an inactive RLK kinase
This study aimed to investigate the biological implications of two overlapping sequences in the Arabidopsis genome, the 3UTR of the PHOT2 gene and a putative AT5G58150 gene, encoded on the complementary strand. AT5G58150 is a probably inactive protein kinase that belongs to the transmembrane, leucin...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2022-12-21 | MSV000090945 | MassIVE
TranscriptomicsProgressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
The 3' untranslated regions (3' UTRs) of mRNAs contain cis-acting elements for posttranscriptional regulation of gene expression. Here, we report that mouse genes tend to express mRNAs with longer 3' UTRs as embryonic development progresses. This global regulation is controlled by alternative polyad...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23871 | biostudies-arrayexpress
Transcriptomics3'UTR sequencing of C.elegans strains
3'UTR sequencing was performed in indicated C.elegans strains to obtain information about alterations in 3'UTR lengths and alternative polyadenylation events.
ORGANISM(S): Caenorhabditis elegans 
2021-09-03 | E-MTAB-9147 | biostudies-arrayexpress
ProteomicsHuman CK1 alpha (CK1α) 5'UTR-interacting proteins
We used tobramycin-affinity RNA-pulldown assays coupled with mass spectrometry to identify CK1α 5'-UTR-binding proteins.
ORGANISM(S): Homo sapiens (Human) 
2022-10-01 | PXD027124 | Pride
Cancer Ck1a Ras Translation 
Genomics3'UTR sequencing of C.elegans strains
3'UTR sequencing of C.elegans strains
PRJEB38630 | ENA
GenomicsIntermolecular 3′UTR-3′UTR interactions drive Wnt gene activation through heteromeric protein assembly
Intermolecular 3′UTR-3′UTR interactions drive Wnt gene activation through heteromeric protein assembly
PRJNA1461925 | ENA
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