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TranscriptomicsGenes regulated by DEG-35, a dual degrader of IKZF2 and CK1A in AML cells
To investigate the genes regulated in MOLM-13 cells treated with DMSO or DEG-35, a dual degrader of IKZF2 and CK1A in AML cells
ORGANISM(S): Homo sapiens 
2023-01-16 | GSE220707 | GEO
GenomicsGenes regulated by DEG-35, a dual degrader of IKZF2 and CK1A in AML cells
Genes regulated by DEG-35, a dual degrader of IKZF2 and CK1A in AML cells
PRJNA911208 | ENA
TranscriptomicsAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
To characterize the role of CK1 (encoded by Csnk1a1) in skin physiology, we crossed mice with floxed Csnk1a1 with mice expressing K14CreERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively in keratinocytes (SKO). In addition, we established K14CreERT2 CK1/p53 double-k...
ORGANISM(S): Mus musculus 
2017-08-25 | E-MTAB-5442 | biostudies-arrayexpress
ProteomicsTMT analysis of MOLM-13 cells treated with series 3 CK1a degraders
Targeted Protein Degradation (TPD) encompasses two approaches that generate small molecules with similar proteasome-dependent mechanisms of action: Proteolysis-Targeting Chimeras (PROTACs) and Molecular Glues (MGs). Our goal is to develop novel MG approaches that exploit the E3 ubiquitin ligase Cere...
ORGANISM(S): Homo sapiens (Human) 
2023-12-01 | PXD045230 | Pride
Acute leukemia Targeted protein degradation Tmt Molecular glues Lc-ms/ms 
GenomicsHomo sapiens
Transcriptomic profiling of AML cell lines MV4-11 and Kasumi-1 treated with CK1a degrader PinA1
PRJNA1446174 | ENA
ProteomicsWnt signaling inhibits Casein kinase 1a activity by modulating its interaction with Protein phosphatase 2A
The mechanism by which Wnt signaling, an essential pathway controlling development and disease, stabilizes beta-Catenin has been a subject of debate over the last three decades. Casein kinase 1alpha (CK1a) functions as a pivotal negative regulator of this signaling pathway, initiating the events tha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095904 | MassIVE
ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD063855 | Pride
Biotin Apex Lc-ms Cgas/ting Ap-ms Ck1-alpha 
UnknownEpigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma.
Not available
S-EPMC7598052 | biostudies-literature
UnknownStructure of the frequency-interacting RNA helicase: a protein interaction hub for the circadian clock.
Not available
S-EPMC4969578 | biostudies-literature
GenomicsToxoplasma gondii GT1
Toxoplasma gondii GT1 Transcriptome or Gene expression
PRJNA287754 | ENA
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