Sort   by:  
 Page size 
TranscriptomicsCharacterizing the contrasting roles of JMJD3 and UTX histone demethylases in T cell acute lymphoblastic leukemia [short_hairpins_RNA-seq]
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we abrogated the expression of JMJD3 (KDM6B) and UTX (KDM6A) H3K27me3 demethylases in human T-ALL lines and assayed for genome-wide expression ...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56689 | biostudies-arrayexpress
GenomicsThe H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [ChIP-Seq]
Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing pro...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-37821 | biostudies-arrayexpress
TranscriptomicsUTX regulated genes in mouse embryonic stem cells
UTX gene is localized on the X chromosome, identified as a demethylase on histone H3 lysine 27. Two independent UTX conditional knockout (cKO) embryonic stem cell lines and two UTX knockout (KO) cell lines were cultured on 0.1% gelatin-coated dishes without feeder cells at desity of 1 million cells/...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-35415 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of primary myoblasts from mice with a satellite cell specific knockout of the histone demthylase UTX/KDM6A
The KDM6 histone demethylases (UTX/KDM6A and JMJD3/KDM6B) mediate removal of repressive histone H3K27me3 marks to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a ...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69968 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner
This SuperSeries is composed of the following subset Series: GSE39472: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data] GSE39473: The X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agil...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39222 | biostudies-arrayexpress
GenomicsAn essential role for UTX in resolution and activation of bivalent promoters
In the present study, we show that UTX plays an essential role in resolving and activating many retinoic acid (RA)-inducible bivalent genes during the RA-driven differentiation of mouse ESCs treated with a physiologically relevant RA concentration (0.2 μM). We showed that UTX loss and UTX knockdown...
ORGANISM(S): Mus musculus 
2016-02-05 | E-GEOD-76692 | biostudies-arrayexpress
ProteomicsUtx interactome in mouse myeloid progenitor cells
Immunoprecipitation of Utx followed by mass spectrometry analysis to identify Utx binding partners in mouse myeloid progenitor cells.
ORGANISM(S): Mus musculus (Mouse) 
2018-04-30 | PXD005011 | Pride
Protein interactions Affinity purification Utx Immunoprecipitation Interactome 
TranscriptomicsUTX Chromatin Immunoprecipitation on human HG18 Nimblegen 2 array promoter set
UTX binding sites were located genome wide in primary human fibroblasts (foot and lung) Tiled promoters with a probe per 100bp of refseq known genes 3kb upstream and 700 bp downstream of transcriptional start 8 samples (2 cell types (foot and lung primary human fibroblasts) x 2 set promoter arrays x...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-16221 | biostudies-arrayexpress
GenomicsX-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data]
Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the repressive H3K27me3 modification play an important role in the activation of M-bM-^...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-39472 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in mature OT-II TCR transgenic CD4 SP thymocytes, either Jmjd3- and Utx-deficient or -sufficient.
The biological functions of histone demethylases Jmjd3 and Utx remain poorly understood. We assessed such functions in developing T cells, using conditional (CD4-Cre-mediated) gene disruption, by inactivating Kdm6a and Kdm6b, respectively encoding Utx and Jmjd3, in immature CD4+CD8+ thymocytes. We c...
ORGANISM(S): Mus musculus 
2015-09-17 | E-GEOD-70363 | biostudies-arrayexpress
Sort   by:  
 Page size