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MetabolomicsChemodiverse cell systems responses to UV in an algal sister of land plants

Plant terrestrialization necessitated overcoming a barrage of stressors. Embryophytes (land plants) use an integrated response network to adjust their molecular physiology in response to terrestrial stressors—one of the important stressors is UV irradiance. The zygnematophytes are the closest str...

2026-07-01 | MTBLS8088 | MetaboLights
TranscriptomicsIdentification of intermediate-sized non-coding RNAs involved in the UV-induced DNA damage response in C. elegans
We utilized high-throughput RNA-seq to uncover the intermediate-sized noncoding RNAs invovled in UV-DNA Damage Responses in C. elegans. 450 novel transfrags were discovered, some of which show dramatic expression change between the UV irradiation and control. This study should lead to a better under...
ORGANISM(S): Caenorhabditis elegans 
2012-05-01 | E-GEOD-37063 | biostudies-arrayexpress
MetabolomicsFlavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling

Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. While these metabolites protect against light damage, their roles in modulating photoreceptor responses remain unclear. Here we show that naringenin chalcone (N...

2025-07-30 | MTBLS12792 | MetaboLights
TranscriptomicsRNA-seq experiment of V79 cells treated with UV light and incubated either in monoculture or coculture with untreated cells
UV-treated cells were stained in green and seeded in density-matched monoculture with equally treated cells or in co-culture with untreated cells. The cultures were kept for 12 h prior to cell sorting and RNA isolation for bulk RNA sequencing. We wanted to compare transcriptional signatures of the ...
ORGANISM(S): Cricetulus griseus 
2026-03-09 | E-MTAB-15733 | biostudies-arrayexpress
TranscriptomicsUV (UVC, 40J/m2) light irradiation effect on human hepatoma Hep3B cells
human hepatoma Hep3B cells were treated with 40 J/m2 UV light versus untreated Alternative pre-mRNA processing plays a key role in the response to DNA damage as well as in neoplastic transformation. We found that two Ewing Sarcoma (ES) cell lines exhibit different sensitivity to UV light irradiation...
ORGANISM(S): Homo sapiens 
2015-02-06 | E-GEOD-65676 | biostudies-arrayexpress
GenomicsTRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism/Seckel syndrome. We establish that TRAIP relocali...
EGAS00001001501 | EGA
MetabolomicsPhytohormone profiling in Nicotiana benthamiana leaves upon mechanical damage and whitefly infestation

Jasmonic and salicylic acids are the major hormones involved in plant response to pests and pathogens. Non-invasive imaging of these hormones at the tissue and whole-organism levels has remained challenging. Here, we engineer autoluminescent plants that report activity of salicylic and jasmonic a...

2025-12-05 | MTBLS13465 | MetaboLights
ProteomicsPosttranslational modifications regulate cellular responses upon UV-induced DNA damage
SUMOylation is a posttranslational protein modification which is characterized by the covalent attachment of a small 11kDa protein, called Small Ubiquitin-like MOdifier (SUMO). SUMOylation plays a pivotal role in a multitude of cellular pathways including cellular responses upon DNA damage. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD010609 | Pride
Human Post-translational modification Sumoylation Dna damage Csb Csa 
TranscriptomicsTranscription profiling of human skin fibroblasts to low and high doses of UVC radiation to assess cellular transcriptional responses to UVC-induced DNA damage
DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional responses to UVC-induced DNA damage we compared time course responses of human skin fibroblasts to l...
ORGANISM(S): Homo sapiens 
2007-09-21 | E-GEOD-713 | biostudies-arrayexpress
ProteomicsThe ribotoxic stress response drives UV-mediated cell death.
Supporting raw MS data for paper (doi: 10.1016/j.cell.2024.05.018) by Sinha N.K. et al, titled "The ribotoxic stress response drives UV-mediated cell death". Index of MS files and labels Table S1 - HaCaT Timecourse. 1-1 - Proteome (AO3604-3627 | Unimod:35; 2016; 4 | 126 -UT_01; 127n - UT_02; 12...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-25 | MSV000092521 | MassIVE
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