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TranscriptomicsExpression Data from Uveal Melanoma primary tumors.
A high percentage of uveal melanoma patients develop metastatic tumors that predominately occur in the liver. To identify genes associated with metastasis in this pathology, we studied 63 molecular profiles derived from gene expression microarrays performed from enuceated primary tumors. Metastasis ...
ORGANISM(S): Homo sapiens 
2010-12-14 | E-GEOD-22138 | biostudies-arrayexpress
TranscriptomicsSyntenin-1 is expressed in uveal melanoma and correlates with metastatic progression
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, being at that time almost always fatal. Identification of patients at high risk of metastases may provide indication for a frequent follow-up for early detection of metastases and treatment. The analysis...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-27831 | biostudies-arrayexpress
TranscriptomicsGene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines
Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactiv...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-48863 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human uveal melanoma cell lines 92-1, MP41 and UM22 treated with entinostat, JQ1 or DMSO
As part of the preclinical research for a recently published trial of combination therapy with the HDAC inhibitor entinostat and the PD1 inhibitor pembrolizumab, an experiment was performed to determined the influence of entinostat and the BET inhibitor JQ1 on the transcriptome of three uveal melano...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-11058 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis of hepatic metastases from uveal melanoma
Metastatic uveal melanoma (MUM) is chemoresistant and usually fatal within one year of diagnosis. There is an urgent need to better understand disease pathogenesis, in order to determine key drivers of the metastatic process that could be effectively targeted by therapy. Gene copy number variations ...
ORGANISM(S): Homo sapiens 
2016-05-18 | E-GEOD-69614 | biostudies-arrayexpress
TranscriptomicsChromosomal changes in primary human uveal melanomas [UCSF]
Uveal melanoma is the most common cancer of the eye arising from melanocytes within the choroid, ciliary bodies and iris. Almost half of uveal melanomas metastasize hematogenously to distant organs, most often the liver, where the disease becomes fatal. One of the first genetic alterations to be i...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42739 | biostudies-arrayexpress
TranscriptomicsChromosomal changes in primary human uveal melanomas [RPCI]
Uveal melanoma is the most common cancer of the eye arising from melanocytes within the choroid, ciliary bodies and iris. Almost half of uveal melanomas metastasize hematogenously to distant organs, most often the liver, where the disease becomes fatal. One of the first genetic alterations to be i...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42738 | biostudies-arrayexpress
ProteomicsProteomics of Primary Uveal Melanoma:Insights to Metastasis and Protein Biomarkers
Uveal melanoma metastases are lethal and remain incurable. Quantitative proteomic analysis of 53 metastasizing and 47 non-metastasizing primary uveal melanoma (pUM) was pursued for insights into UM metastasis and protein biomarkers. The metastatic status of the pUM specimens was defined based on cli...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-15 | MSV000087437 | MassIVE
ProteomicsOncogenic pathways in uveal melanoma identified by phosphoproteomic analysis
The uveal melanoma cell lines MP41 and MP46 driven by oncogenic G11 (Q209L) and Gq (Q209L), respectively, and a control cell line OCM-1A driven by oncogenic BRAF (V600E) were treated for 24 hours with FR900359, a highly specific inhibitor of Gq/11. Protein extracts were collected and TMT labeled pri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-11-11 | MSV000090700 | MassIVE
ProteomicsHDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma
Purpose: The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. The current study has used multi-omics approaches and drug screens to identify the pan-HDAC inhibitor panobinostat as an effective strategy to limit MEK inhibitor resistance. Experimental...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013988 | Pride
Uveal melanoma Hdac Abpp 
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