V-dependent er-stabilization

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Caldendrin regulates spine apparatus localization through myosin V-dependent ER-stabilization in dendritic spines

Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs results in a great structural and molecular diversity of dendritic spines. Active spines with large Ca2+-transients are frequently invaded by a...

ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat)

2022-01-27 | PXD029427 | Pride

Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines.

Not available

S-EPMC8844991 | biostudies-literature

BIM is the primary mediator of MYC-induced apoptosis in multiple solid tissues

C-MYC (henceforth MYC) is one of the most frequently overexpressed oncogenes in human cancer and even modestly deregulated MYC expression can initiate ectopic proliferation in many post-mitotic, terminally differentiated cell types in vivo. Metazoan organisms have consequently evolved a number of me...

ORGANISM(S): Homo sapiens

2015-05-18 | E-GEOD-59001 | biostudies-arrayexpress

Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements, part 2

The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...

ORGANISM(S): Homo sapiens (Human)

2019-11-08 | PXD006747 | Pride

Tamoxifen Sprox N-desmethyl tamoxifen

Gene expression signatures of HO-1 in BeWo cells

Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...