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TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
ProteomicsA Subtractive Proteomics Approach for the Identification of Immunodominant Acinetobacter baumannii Vaccine Candidate Proteins
Background: Acinetobacter baumannii is one of the most dangerous multidrug-resistant pathogens worldwide. Currently, 50-70% of clinical isolates of A. baumannii are extensively drug-resistant (XDR) and available antibiotic options against A. baumannii infections are limited. There are still needs to...
ORGANISM(S): Acinetobacter baumannii AYE Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 
2022-11-02 | PXD037507 | Pride
Immunodominant Vaccine candidate Immunoprecipitation Acinetobacter baumannii (a. baumannii) Proteomics 
TranscriptomicsSplenic gene expression profile of mice immunized with an anti-Fasciola hepatica vaccine candidate: insights into the immunological mechanisms leading to protection
Fasciolosis remains an important food-borne tremaode disease causing high morbidity around the world and affecting grazing animals and humans. A deeper understanding concerning the molecular mechanisms by which Fasciola hepatica infection occurs as well as the molecular basis involved in acquiring p...
ORGANISM(S): Mus musculus 
2015-06-06 | E-GEOD-69611 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Peripheral Blood Mononuclear Cells Exposed to Lassa Virus and to the Reassortant ML29, a Vaccine Candidate
The virulent Lassa fever virus (LASV) and the non-pathogenic Mopeia virus (MOPV) infect rodents and incidentally people in West Africa. The mechanism of LASV damage in human beings is unclear. A live-attenuated reassortant of MOPV and LASV protects rodents and primates from Lassa fever disease. Peri...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-41300 | biostudies-arrayexpress
TranscriptomicsUsing next generation sequencing to study the genetic diversity of candidate live attenuated Zika vaccines
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Candidate live-attenuated vaccine (LAV) viruses with engineered deletions in the 3’UTR provide immunity and protection in animal models of ZIKV infection, and phenotypic studies show that LAVs retain pro...
ORGANISM(S): Zika virus 
2020-04-13 | E-MTAB-8905 | biostudies-arrayexpress
MetabolomicsSeed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit
Rice (Oryza sativa L.) is a candidate crop for production of plant-based vaccines by genetic engineering technologies. MucoRice-CTB has been developed as a rice-seed-based vaccine against cholera by transgenic expression of modified cholera toxin B-subunit (CTB) under the RNA interference (RNAi)-med...
2017-08-30 | MTBLS437 | MetaboLights
UnknownSafety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting.
Not available
S-EPMC5845829 | biostudies-literature
GenomicsRNA signatures followed by immunization of multiantigenic adenovirus-based vaccine candidate against mycobacterium tuberculosis
RNA signatures followed by immunization of multiantigenic adenovirus-based vaccine candidate against mycobacterium tuberculosis
PRJNA1101044 | ENA
TranscriptomicsCandidate Vaccine Assessment in a pH1N1 Rhesus Macaque Challenge Model
A mixed-aerosol pH1N1 (Cal04) challenge of rhesus macaques was establised to serve as a pre-clinical model for the evaluation of candidate vaccines. After characterizing the clinical signs and immune responses associated with pH1N1 challenge in naïve rhesus macaques, a follow-up study assessing 2 c...
ORGANISM(S): Macaca mulatta 
2014-10-24 | E-GEOD-60009 | biostudies-arrayexpress
UnknownStabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine.
Not available
S-EPMC6863464 | biostudies-literature
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