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ProteomicsRibosome quality control activity potentiates vaccinia virus protein synthesis during infection
Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in transl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Vaccinia Virus Wr (ncbitaxon:10254) 
2021-01-05 | MSV000086660 | MassIVE
TranscriptomicsDiversity in the polyadenylation and decay of human cellular microRNAs during Vaccinia virus infection
Vaccinia virus (VACV) is a large cytoplasmic dsDNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. Here we use small RNA sequencing to comprehensively quantify the impact of VACV infection on the expression of endogenous small non-coding RNAs (sncRNAs)...
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-54235 | biostudies-arrayexpress
TranscriptomicsStunned silence: gene expression programs in human cells infected with Monkeypox or Vaccinia virus
Three experiments, corresponding to the three figures in the article, are represented in this set. Each experiment was an ex vivo treatment time course as described in the paper. For each of the experiments, mRNA was isolated at the indicated time points, cDNA was directly prepared by reverse transc...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-24125 | biostudies-arrayexpress
ProteomicsNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusNon-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia VirusV
Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historically thought to encode all the proteins required for its replication. However, recent findings have shown that nuclear host proteins are redirected to the cy...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD060689 | Pride
Topoisomerase 2 Replication Vaccinia Lc-ms/ms 
GenomicsOrthopoxvirus vaccinia
Orthopoxvirus vaccinia Raw sequence reads
PRJNA290292 | ENA
TranscriptomicsPermissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
Oncolytic viral therapy represents an alternative therapeutic strategy for the treatment of cancer. This therapy relies on efficient replication of virus in tumor cells in vivo with minimal or no replication in normal tissues. We recently described GLV-1h68 as a modified Vaccinia Virus (VACV) constr...
ORGANISM(S): Homo sapiens 
2012-03-24 | E-GEOD-28472 | biostudies-arrayexpress
GenomicsOrthopoxvirus vaccinia
recombination betweeon co-infecting vaccinia viruses
PRJNA238138 | ENA
GenomicsOrthopoxvirus vaccinia
Orthopoxvirus vaccinia Genome sequencing
PRJNA245317 | ENA
GenomicsOrthopoxvirus vaccinia
Vaccinia virus Post replicative transcription start sites.
PRJNA169009 | ENA
TranscriptomicsTranscription profiling of human Hela cells infected with Vaccinia mutants
Samples were received from the lab of Bertram Jacobs, experiments done by Jeff Langland (langland@asu.edu). Midlog Hela cells were infected with copenhagen strain Vaccinia Virus at MOI of 5. Viral stocks were sucrose pad purified. Incubated 2, 6, and 9 hrs post infection. viral mutants include VC2 (...
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-64 | biostudies-arrayexpress
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