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ProteomicsMebendazole Inhibits Histoplasma capsulatum In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels
Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if treatment is unsuccessful. Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potential...
ORGANISM(S): Fungi Histoplasma capsulatum 
2023-03-22 | PXD033762 | Pride
Histoplasma capsulatum  mebendazole  drug repositioning. antifungal activity Proteomic analysis 
ProteomicsA Bothrops jararaca venom subproteome to benchmark a spectral clustering algorithm by controlling the selection bias
The clustering of mass spectra is a critical component of many proteomics applications. The clustering validation science is just as important, having evolved side by side with the clustering algorithms themselves. In this work, we build on Rieder et al. 's cluster validation framework, and we discu...
ORGANISM(S): Bothrops jararaca (Jararaca) (Bothrops jajaraca) 
2022-03-16 | PXD022124 | Pride
Bothrops jararaca Venomics Spectral clustering Algorithm 
ProteomicsQuantitative proteomic map of the trypanosomatid Strigomonas culicis: the biological contribution of its endosymbiotic bacterium
Strigomonas culicis is a kinetoplastid parasite of insects that maintains a mutualistic association with an intracellular symbiotic bacterium, that is highly integrated into the protozoa metabolism: it furnishes essential compounds and divides in synchrony with the nuclear host. The protozoa, conve...
ORGANISM(S): Strigomonas culicis 
2019-11-08 | PXD013136 | Pride
Endosymbiont-bearing trypanosomatid  proteomics  mass spectrometry  amino acid metabolism Protein synthesis And folding  energetic metabolism 
ProteomicsProteomics reveals virulence-related proteins in Paracoccidioides brasiliensis and Paracoccidioides lutzii yeast cells grown in the presence of L-dihydroxyphenylalanine
Species of the genus Paracoccidioides cause a systemic infection in human patients. Yeast cells of Paracoccidioides spp. produce melanin in the presence of L-dihydroxyphenylalanine and during infection, which may impact the pathogen survival into the host. To better understand the metabolic changes ...
ORGANISM(S): Fungi Paracoccidioides brasiliensis (strain Pb18) Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) 
2021-01-20 | PXD021711 | Pride
L-dihydroxyphenylalanine Proteomics Virulence Melanin Paracoccidioides 
ProteomicsEndosymbiont elimination enhances de novo heme synthesis by the overexpression of a ferrous iron transporter in Strigomonas culicis
The monoxenous trypanosomatid Strigomonas culicis inhabits several mosquito species, including Aedes aegypti. Previously, our group described that the infection of A. aegypti females by this trypanosomatid triggers the insect's immune response, reduces its reproductive fitness, and could potentially...
ORGANISM(S): Candidatus Kinetoplastidibacterium Blastocrithidiae (ex Strigomonas Culicis) Strigomonas Culicis 
2026-01-12 | PXD044748 | panorama
UnknownTitin-related familial dilated cardiomyopathy: factors associated with disease onset.
Not available
S-EPMC12718689 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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