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TranscriptomicsRNA validation of LAB 2k v2
To study their metabolic potential in natural ecosystems, we developed a species-independent LAB microarray, containing 2,269 30-mer oligonucleotides, and targeting 406 genes that play a key role in the production of sugar catabolites, bacteriocins, exopolysaccharides, and aromas, in probiotic and b...
ORGANISM(S): Lactobacillus pontis 
2010-06-21 | E-GEOD-9140 | biostudies-arrayexpress
TranscriptomicsMeta-transcriptome analysis of a natural wheat sourdough ecosystem during a 10-day spontaneous, laboratory fermentation
Lactic acid bacteria (LAB) are of industrial importance in the production of fermented foods, among which sourdough-derived products. Despite their limited metabolic capacity LAB contribute considerably to important characteristics of fermented foods, among which extended shelf-life, microbial safet...
ORGANISM(S): Lactobacillus pontis 
2010-07-07 | E-GEOD-15693 | biostudies-arrayexpress
TranscriptomicsMeta-transcriptome analysis of a natural wheat sourdough ecosystem during a 10-day spontaneous laboratory fermentation
Lactic acid bacteria (LAB) are of industrial importance in the production of fermented foods, among which sourdough-derived products. Despite their limited metabolic capacity LAB contribute considerably to important characteristics of fermented foods, among which extended shelf-life, microbial safet...
ORGANISM(S): Pediococcus acidilactici 
2010-07-07 | E-GEOD-15686 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ovarium cancer samples from patients with tumors of different stages and sensitivity to platinum chemotherapy treatment
We investigated whether prognostic information is reflected in the expression patterns of ovarian carcinoma samples. RNA obtained from seven FIGO stage I without recurrence, seven platin-sensitive advanced-stage (III or IV), and six platin-resistant advanced-stage ovarian tumors was hybridized on a ...
ORGANISM(S): Homo sapiens 
2007-02-10 | E-MEXP-979 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of NIPP1 and EZH2 in human prostate cell line PC-3 to investigate whether they regulate a common set of genes
NIPP1 and EZH2 contribute to the silencing of a common set of genes. Since both NIPP1 and EZH2 turned out to be essential for the initiation and maintenance of global H3K27 trimethylation, a key step in the PcG-mediated transcriptional regulation of genes, we have subsequently examined by DNA-micro...
ORGANISM(S): Homo sapiens 
2007-08-21 | E-TABM-128 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of multiple mouse myeloma (MM) cells during intra-medullary progression in the 5T2MM mouse model
Insights into mechanisms involved during intra-medullary myeloma progression could be helpful in the better understanding of this disease and in the development of new therapeutical strategies. Herein gene expression profile of multiple myeloma (MM) cells during intra-medullary progression was inves...
ORGANISM(S): Mus musculus 
2008-03-27 | E-MEXP-186 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NF1 heterozygous (NF1+/-) melanocytes from a Neurofibromatosis type 1 patient and NF1 wild type (NF1+/+) melanocytes of a healthy control patient
One of the major primary features of the neurocutaneous genetic disorder Neurofibromatosis type 1 are the hyperpigmentary café-au-lait macules where dysregulation of melanocyte development, proliferation and differentiation is considered to play a key etiopathogenic role. To gain better insight in t...
ORGANISM(S): Homo sapiens 
2005-02-05 | E-MEXP-258 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary hippocampal neurons isolated from mouse E17 embryos and undergoing differentiation in the culture for 7h, 18h, 33h, 72h, 8 days, 12 days (at which time points the RNA was extracted) vs RNA isolated from a newborn brain
A time-course experiment, in which the gene expression in the primary hippocampal neurons isolated from E17 embryos and undergoing differentiation in the culture for 7h, 18h, 33h, 72h, 8 days, 12 days (at which time points the RNA was extracted) was compared by competitive hybridization with a commo...
ORGANISM(S): Mus musculus 
2003-06-01 | E-MEXP-11 | biostudies-arrayexpress
TranscriptomicsThe effects of mismatches on hybridization in DNA microarrays: determination of nearest neighbor parameters
Quantifying interactions in DNA microarrays is of central importance for a better understanding of their functioning. Hybridization thermodynamics for nucleic acid strands in aqueous solution can be described by the so-called nearest-neighbor model, which estimates the hybridization free energy of ...
ORGANISM(S): synthetic construct 
2010-05-22 | E-GEOD-14547 | biostudies-arrayexpress
TranscriptomicsLactobacillus plantarum IMDO 130201, a wheat sourdough isolate, adapts to growth in wheat sourdough simulation medium at different pH values through differential gene expression
Sourdough is a very competitive and challenging environment for microorganisms. Usually, a stable microbiota composed of lactic acid bacteria (LAB) and yeasts comes to dominate this ecosystem. Although rich in carbohydrates, thus providing an ideal environment to grow, the low pH presents a particul...
ORGANISM(S): Lactobacillus plantarum 
2011-07-31 | E-GEOD-23945 | biostudies-arrayexpress
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