Sort   by:  
 Page size 
UnknownA Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers.
Not available
S-EPMC6024727 | biostudies-literature
ProteomicsChoroid plexus targeted gene therapy for the treatment of post-hemorrhagic hydrocephalus
A subset of infants and adults with hemorrhagic stroke and intraventricular hemorrhage (IVH) ultimately develop a life-threatening accumulation of cerebrospinal fluid (CSF), termed post-hemorrhagic hydrocephalus (PHH). An incomplete understanding of this variably progressive condition has hampered t...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD039738 | Pride
Liquid chromatography Mass spectrometry Mouse plasma proteomics 
TranscriptomicsTranscription profiling of human ulcerative colitis samples reveals a predictive response signature to infliximab treatment in ulcerative colitis
Infliximab, an anti-TNFa monoclonal antibody, is an effective treatment for ulcerative colitis (UC) inducing over 60% of patients to respond to treatment. Consequently, about 40% of patients do not respond. This study analyzed mucosal gene expression from patients enrolled in ACT1 to provide a predi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-12251 | biostudies-arrayexpress
ProteomicsA single immunization with CAF08 provides newborns with Th1-mediated protection against Respiratory Syncytial Virus infection
Respiratory Syncytial Virus (RSV) is a leading cause of morbidity and mortality in children, due in part to their distinct immune system, characterized by impaired induction of T-helper 1 (Th1)‐immunity. Here we describe cationic adjuvant formulation (CAF)-08, a liposomal vaccine formulation tailore...
ORGANISM(S): Homo sapiens (Human) 
2022-06-14 | PXD025568 | Pride
Human Dendritic cell Vaccine Rsv Newborn 
TranscriptomicsMucosal expression profiling in patients with inflammatory bowel disease before and after first infliximab treatment
We used microarrays to identify mucosal gene signatures predictive of response to infliximab (IFX) in patients with inflammatory bowel disease (IBD) and to gain more insight into the pathogenesis of IBD. Keywords: drug response and treatment effect Mucosal biopsies were obtained at endoscopy in act...
ORGANISM(S): Homo sapiens 
2009-11-02 | E-GEOD-16879 | biostudies-arrayexpress
TranscriptomicsMucosal gene signatures to predict response to infliximab in patients with ulcerative colitis
Infliximab, an anti-TNF-alpha monoclonal antibody, is an effective treatment for ulcerative colitis (UC) with over 60% of patients responding to treatment and up to 30% reaching remission. The mechanism of resistance to anti-TNF-alpha is unknown. This study used colonic mucosal gene expression to pr...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-GEOD-14580 | biostudies-arrayexpress
ProteomicsUrine Proteomics for Noninvasive Monitoring of Biomarkers in Bronchopulmonary Dysplasia
Current techniques to diagnose and/or monitor critically ill neonates with bronchopulmonary dysplasia (BPD) require invasive sampling of body fluids, which can affect the health status of these frail neonate. We tested our hypotheses 1) it is feasible to use early urine samples from extremely low g...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028895 | Pride
Extremely low gestational age newborn Mass spectrometry Chronic lung disease 
UnknownWhole genome sequence analysis of the first Australian OXA-48-producing outbreak-associated Klebsiella pneumoniae isolates: the resistome and in vivo evolution.
Not available
S-EPMC3612081 | biostudies-literature
ProteomicsAre Mouse Models a surrogate for human disease? A temporal, quantitative and molecular perspective.
It is unclear to what extent Tau molecular pathology in murine models reflect human Tauopathies. Nevertheless, mouse models that overexpress human mutant Tau (P301S and P301L) are widely used in studies of Tauopathies and Alzheimer’s Disease (AD). In this study, we perform an in-depth temporally and...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD033965 | Pride
Are mouse models a surrogate for human disease? a temporal Quantitative and molecular perspective. 
TranscriptomicsColonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice
The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphat...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-42768 | biostudies-arrayexpress
Sort   by:  
 Page size