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TranscriptomicsImpact of monomeric and oligomeric flavanols (MOF) consumption on the gene expression profile of leukocytes (human)
Background: In a recent intervention study, the daily supplementation with 200mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene exp...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54325 | biostudies-arrayexpress
TranscriptomicsDietary flavanols modulate the transcription of genes involved in cardiovascular pathology with complex changes of their DNA methylation state
Background: In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene ex...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54643 | biostudies-arrayexpress
TranscriptomicsWhole-genome saliva and blood DNA methylation patterns in individuals with a respiratory allergy
It has been suggested that the etiology of respiratory allergies (RA) can be partly explained by DNA methylation changes caused by adverse environmental and lifestyle factors experienced early in life. Longitudinal, prospective studies can aid in the unravelment of the epigenetic mechanisms involved...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-73745 | biostudies-arrayexpress
GenomicsA genome-wide search for epigenetically regulated genes in zebra finch using MethylCap-seq and RNA-seq
DNA methylation is tightly linked with gene expression regulation and has long been regarded a stable epigenetic mark in postmitotic cells. However, it recently became clear that postnatal brains appear to show stimulus-induced de novo CpG methylation or active demethylation related to neuronal plas...
ORGANISM(S): Taeniopygia guttata 
2015-12-10 | E-GEOD-61060 | biostudies-arrayexpress
TranscriptomicsPharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Withaferin A isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied in epithelial-l...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-53049 | biostudies-arrayexpress
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