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TranscriptomicsThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
We investigate the role of Snf2l in ovaries by characterizing a mouse bearing an inactivating deletion on the ATPase domain of Snf2l (Ex6DEL). Snf2l mutant mice produce significantly fewer eggs than control mice when superovulated. Thus, gonadotropin stimulation leads to a significant deficit in sec...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-42997 | biostudies-arrayexpress
TranscriptomicsMutant p53 in fallopian tube epithelium and high-grade serous cancer formation
Ovarian cancer is the fifth leading cause of cancer death among US women. Evidence supports the hypothesis that high-grade serous ovarian cancers (HGSC) may originate in the distal end of the fallopian tube. Although a heterogeneous disease, 96% of HGSC contain mutations in p53. In addition, the ...
ORGANISM(S): Mus musculus 
2014-10-25 | E-GEOD-62694 | biostudies-arrayexpress
TranscriptomicsExpression data from M0505 and STOSE murine ovarian surface epithelial cell lines
Our lab established the M0505 cell line from the ovarian surface epithelium (OSE) of FVB/N mice in May 2005 in order to study OSE biology. This cell line spontaneously transformed into the spontaneously transformed OSE (STOSE) cell line in mid 2012. We used microarrays to try to determine the molecu...
ORGANISM(S): Mus musculus 
2014-02-04 | E-GEOD-54633 | biostudies-arrayexpress
Transcriptomics17β-estradiol accelerates ovarian tumour progression in vivo though the upregulation of GREB1
Exogenous 17β-estradiol (E2) accelerates the progression of ovarian cancer in the transgenic tgCAG-LS-TAg mouse model of the disease. We hypothesized that E2 has direct effects on ovarian cancer cells and this study was designed to determine the molecular mechanisms by which E2 accelerates ovarian t...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-45271 | biostudies-arrayexpress
TranscriptomicsExpression data from M0505 (with and without PAX2) murine ovarian surface epithelial cell lines
Our lab established the M0505 cell line from the ovarian surface epithelium (OSE) of FVB/N mice in May 2005 in order to study OSE biology. This cell line was infected with PAX2 to study the biological consequences of PAX2 expression in normal mOSE cells We used microarrays to try to determine the do...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-69238 | biostudies-arrayexpress
GenomicsEGAD00000000048
Sequencing data from oestrogen-receptor-alpha-positive metastatic lobular breast cancer sample
EGAD00000000048 | EGA
GenomicsEGAD00000000049
RNA-SEQ data from oestrogen-receptor-alpha-positive metastatic lobular breast cancer sample
EGAD00000000049 | EGA
GenomicsMutational evolution in a lobular breast tumour profiled at single nucleotide resolution
We have used next generation sequencing to sequence genomes (>43-fold coverage) and transcriptomes of an oestrogen-receptor-alpha-positive metastatic lobular breast cancer at depth. We found 32 somatic non-synonymous coding mutations present in the metastasis, and measured the frequency of these som...
EGAS00000000054 | EGA
GenomicsEGAD00000000047
Signal data for from 3 recurrent and 1 ovarian primary Granulosa Cell Tumour samples
EGAD00000000047 | EGA
GenomicsEGAD00000000046
RNA-SEQ data from 3 recurrent and 1 ovarian primary Granulosa Cell Tumour samples
EGAD00000000046 | EGA
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