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TranscriptomicsGene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples
In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated i...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-74000 | biostudies-arrayexpress
TranscriptomicsComparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver
At present, substantial efforts are focused on the development of in vitro assays coupled with M-bM-^@M-^]omicsM-bM-^@M-^] technologies for the identification of carcinogenic substances as an alternative to the classical 2-year rodent carcinogenicity bioassay. A prerequisite for the eventual regulat...
ORGANISM(S): Rattus norvegicus 
2012-04-23 | E-GEOD-36524 | biostudies-arrayexpress
TranscriptomicsAnalyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposu...
ORGANISM(S): Rattus norvegicus 
2013-02-20 | E-GEOD-40117 | biostudies-arrayexpress
TranscriptomicsEvaluation of the robustness of classification of carcinogen-modified transcriptomic responses in HepaRG cells and the interlaboratory reproducibility of the model
Efforts to develop alternatives which can at least partially replace some of the currently used in vivo tests are ongoing. The recently ended FP6 European project carcinoGENOMICS had the goal to use the combination of toxicogenomics and in vitro cell culture models for identification of genotoxic- a...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-48990 | biostudies-arrayexpress
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