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MetabolomicsComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 20...

2024-03-07 | MTBLS7670 | MetaboLights
ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
ProteomicsTauroursodeoxycholic acid-induced neural stem cell proliferation
Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhances adult NSC pool in vitro and in vivo. In this study, we dissected the mechanism triggered by this proliferation-inducing molecule, namely in mediating metabo...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017979 | Pride
Lc-msms Mouse Neuronal stem cells 
ProteomicsTuberculosis diagnostic biomarker signature by proteomics and metabolomics
: Tuberculosis (TB) is a transmissible disease listed as one of the 10 leading causes of death worldwide (10 million infected in 2019). A swift and precise diagnosis is essential to forestall its transmission, for which is crucial the discovery of effective diagnostic biomarkers. In this study, we a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037341 | Pride
Tuberculosis  diagnosis  biomarkers  multiomics  mass-spectrometry  blood serum 
UnknownMore than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium.
Not available
S-EPMC9630195 | biostudies-literature
MetabolomicsFunctional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming
The axolotl (Ambystoma mexicanum) is a caudate amphibian, which has an extraordinary ability to restore a wide variety of damaged structures by a process denominated epimorphosis. While the origin and potentiality of progenitor cells that take part during epimorphic regeneration are known to ...
2021-11-04 | MTBLS1708 | MetaboLights
UnknownA multilocus phylogeny of the fish genus Poeciliopsis: Solving taxonomic uncertainties and preliminary evidence of reticulation.
Not available
S-EPMC6392363 | biostudies-literature
UnknownPhenotypic plasticity, genetic structure, and systematic position of Neoechinorhynchus emyditoides Fisher, 1960 (Acanthocephala: Neoechinorhynchidae) a parasite of emydid turtles from the Nearctic and Neotropical regions.
Not available
S-EPMC10090580 | biostudies-literature
UnknownMicrodiversity Shapes the Seasonal Niche of Prokaryotic Plankton Inhabiting Surface Waters in a Coastal Upwelling System.
Not available
S-EPMC12280048 | biostudies-literature
UnknownIdentification of lncRNAs Deregulated in Epithelial Ovarian Cancer Based on a Gene Expression Profiling Meta-Analysis.
Not available
S-EPMC10341812 | biostudies-literature
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