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TranscriptomicsBulk RNAseq of anti-PD1-induced cardiac dysfunction in C57BL/6J mice
C57BL6/J mice were treated with anti-PD-1 for 2 or 4 weeks, or with isotype control antibody. In echocardiography, cardiac dysfunction was seen both after 2 and 4 weeks, with decreased ejection fraction and left ventricular dilation. Bulk RNA sequencing of the hearts after treatment was performed to...
ORGANISM(S): Mus musculus 
2022-12-03 | E-MTAB-12388 | biostudies-arrayexpress
UnknownEarly growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses.
Not available
S-EPMC3791870 | biostudies-literature
UnknownAn orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis.
Not available
S-EPMC6081386 | biostudies-literature
ProteomicsThe Human Melanoma Proteome Atlas – Defining the Molecular Pathology & Complementing the Melanoma Transcriptome
This project is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization from this project were determined for a broad spectrum of diverse, surgically isolated melanoma tu...
ORGANISM(S): Homo sapiens (Human) 
2021-07-16 | PXD026086 | Pride
Proteogenomics Histopathology Heterogeneity Braf Phosphorylation Driver mutations Metastatic malignant melanoma Sub-cellular localization Acetylation stoichiometry Post-translational-modification 
UnknownA20 suppresses canonical Smad-dependent fibroblast activation: novel function for an endogenous inflammatory modulator.
Not available
S-EPMC5048449 | biostudies-literature
UnknownMAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.
Not available
S-EPMC6188229 | biostudies-literature
MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
UnknownNrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.
Not available
S-EPMC7205471 | biostudies-literature
TranscriptomicsGenes Required for and Effects of Inducible Alginate Overproduction by Growth of Pseudomonas aeruginosa on PIAAMV
Pseudomonas aeruginosa is an opportunistic pathogen that can adapt to changing environments and can secrete an exopolysaccharide known as alginate as a protection response resulting in a colony morphology and phenotype referred to as mucoid. However how P. aeruginosa senses its environment and acti...
ORGANISM(S): Pseudomonas aeruginosa 
2013-07-15 | E-GEOD-48429 | biostudies-arrayexpress
UnknownPulmonary Leiomyomatosis in a Postmenopausal Patient After Previous Hysterectomy: A Case Report.
Not available
S-EPMC12854095 | biostudies-literature
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