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ProteomicsMultiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress
In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-03-03 | PXD040214 | Pride
P.r239c mutation Danio rerio Alexander disease Gfap Zebrafish 
TranscriptomicsPrenatal arsenic exposure and the epigenome: Identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes
Prenatal exposure to inorganic arsenic (iAs) is detrimental to the health of newborns and increases the risk of disease development later in life. Here we examined a subset of newborn cord blood leukocyte samples collected from mothers enrolled in the Biomarkers of Exposure to ARsenic (BEAR) pregnan...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-62924 | biostudies-arrayexpress
UnknownA multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease.
Not available
S-EPMC11915002 | biostudies-literature
UnknownProduction of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming.
Not available
S-EPMC9420913 | biostudies-literature
TranscriptomicsTumor gene expression analysis - PI3K Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma
Of the 142 patients enrolled in Study CHRONOS-1, an open-label, single-arm, Phase II study evaluating the efficacy and safety of single-agent copanlisib in patients with relapsed or refractory, indolent B-cell lymphoma (NCT01660451; Part B), 96 archival formalin-fixed paraffin-embedded tumor tissues...
ORGANISM(S): Homo sapiens 
2017-12-01 | E-MTAB-6088 | biostudies-arrayexpress
TranscriptomicsDNA methylation patterns associated with arsenicosis
DNA methylation patterns were analyzed in blood samples from humans unexposed or exposed to arsenic Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-26073 | biostudies-arrayexpress
UnknownEfficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.
Not available
S-EPMC7787219 | biostudies-literature
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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