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ProteomicsGermline maintenance through the multifaceted activities of GLH/Vasa in Caenorhabditis elegans P granules
Vasa is a highly conserved member of the ATP-dependent DEAD box helicase family, a multipotency factor, and a critical component for the specification and maintenance of the germline. Its homologs have been shown to regulate translation, small RNA amplification, and serve as a molecular solvent for ...
ORGANISM(S): Caenorhabditis elegans 
2019-06-07 | PXD014135 | Pride
Vasa C. elegans Glh-1 Glh-1 coip 
TranscriptomicsRNA clamping by Vasa assembles a piRNA Amplifier complex on transposon transcripts
Germline-specific Piwi-interacting RNAs (piRNAs) protect the genome against selfish genetic elements and are essential for fertility in animals. piRNAs targeting active transposons are amplified by a feed-forward loop known as the Ping-pong cycle, which links endonucleolytic slicing of target RNA...
ORGANISM(S): Bombyx mori 
2014-06-04 | E-GEOD-57420 | biostudies-arrayexpress
ProteomicsGLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance
The ability to distinguish non-self from self is the key characteristic for any defense system. piRNAs function as guardians of the genome by silencing non-self nucleic acids and transposable elements in animals. Many piRNA factors are enriched in perinuclear germ granules, but whether their localiz...
ORGANISM(S): Caenorhabditis elegans 
2022-08-05 | PXD033506 | Pride
Glh-1 Vasa 
UnknownGermline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules.
Not available
S-EPMC6827368 | biostudies-literature
UnknownInpatient vs outpatient management of pregnancies with vasa previa: A historical cohort study.
Not available
S-EPMC10577631 | biostudies-literature
TranscriptomicsUAP56 couples piRNA clusters to the perinuclear transposon silencing machinery [RNA-Seq and RIP-Seq]
The transposon silencing piRNAs are produced from precursors that are encoded by heterochromatic clusters and processed in the perinuclear nuage. We show that the Drosophila nuclear DEAD box protein UAP56, previously implicated in mRNA splicing and nuclear export, co-localizes with the cluster-assoc...
ORGANISM(S): Drosophila melanogaster 
2012-11-28 | E-GEOD-35637 | biostudies-arrayexpress
TranscriptomicsUAP56 couples piRNA clusters to the perinuclear transposon silencing machinery [tiling array]
The transposon silencing piRNAs are produced from precursors that are encoded by heterochromatic clusters and processed in the perinuclear nuage. We show that the Drosophila nuclear DEAD box protein UAP56, previously implicated in mRNA splicing and nuclear export, co-localizes with the cluster-assoc...
ORGANISM(S): Drosophila melanogaster 
2012-11-28 | E-GEOD-35636 | biostudies-arrayexpress
TranscriptomicsThe Vasa homolog RDE-12 engages target mRNA and a secondary-Argonaute WAGO-1 to promote RNAi in C. elegans
Argonaute proteins (AGOs) are key nuclease effectors of RNA interference (RNAi) [1]. Although purified AGOs can mediate a single round of target-RNA cleavage in vitro, accessory factors are required for siRNA loading and to achieve multiple-target turnover [2, 3]. To identify AGO co-factors we immun...
ORGANISM(S): Caenorhabditis elegans 
2014-06-24 | E-GEOD-54396 | biostudies-arrayexpress
GenomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [smallRNA-seq]
Condensates that accumulate small RNA biogenesis factors (nuage) are common in germ cells and often associate with nuclei. In the C. elegans germline, P granules overlay large clusters of nuclear pores and this organization has been proposed to facilitate surveillance of nascent transcripts by Argon...
ORGANISM(S): Caenorhabditis elegans 
2025-03-16 | GSE291761 | GEO
TranscriptomicsFG repeats drive co-clustering of nuclear pores and P. granules in the C elegans germline [RNA-seq]
Condensates that accumulate small RNA biogenesis factors (nuage) are common in germ cells and often associate with nuclei. In the C. elegans germline, P granules overlay large clusters of nuclear pores and this organization has been proposed to facilitate surveillance of nascent transcripts by Argon...
ORGANISM(S): Caenorhabditis elegans 
2025-03-16 | GSE291760 | GEO
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