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ProteomicsGermline maintenance through the multifaceted activities of GLH/Vasa in Caenorhabditis elegans P granules
Vasa is a highly conserved member of the ATP-dependent DEAD box helicase family, a multipotency factor, and a critical component for the specification and maintenance of the germline. Its homologs have been shown to regulate translation, small RNA amplification, and serve as a molecular solvent for ...
ORGANISM(S): Caenorhabditis elegans 
2019-06-07 | PXD014135 | Pride
Vasa C. elegans Glh-1 Glh-1 coip 
TranscriptomicsAnalysis of gene expression and polysome profiling in the presence and absence of glh-1 in C. Elegans
This experiment compares gene expression and polysome profiling between a strain where glh-1 is present - DUP64 glh-1(sam24[glh-1::gfp::3xFlag]) I and a strain where the glh-1 coding sequence has been deleted DUP144 glh-1(sam65[Δglh-1::gfp::3xFlag]) I
ORGANISM(S): Caenorhabditis elegans 
2022-11-22 | GSE148737 | GEO
GenomicsAnalysis of gene expression and polysome profiling in the presence and absence of glh-1 in C. Elegans
Analysis of gene expression and polysome profiling in the presence and absence of glh-1 in C. Elegans
PRJNA625528 | ENA
UnknownC. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs.
Not available
S-EPMC3031674 | biostudies-literature
UnknownGLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline.
Not available
S-EPMC9677334 | biostudies-literature
UnknownThe Dynamics of P Granule Liquid Droplets Are Regulated by the Caenorhabditis elegans Germline RNA Helicase GLH-1 via Its ATP Hydrolysis Cycle.
Not available
S-EPMC7268986 | biostudies-literature
TranscriptomicsDEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene...
ORGANISM(S): Caenorhabditis elegans 
2010-05-26 | E-GEOD-9993 | biostudies-arrayexpress
ProteomicsWAGO-4 Localization to Germ Granules Is Important for Its Accurate Small RNA Loading
There were several MS experiments used in this study: 1) Proximity labeling of the P granules 2) Protein levels estimation from whole worm lysates and 3) wago-4 KO expression check (PRM analysis). 1) Proximity labeling strategy was used to estimate P granule composition in 3xFG mutant (FG domains of...
ORGANISM(S): Caenorhabditis elegans 
2025-10-14 | PXD062557 | Pride
C. elegans Proximity labeling Fg repeats P granules 
OtherA family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing [IP small-RNA seq]
Germline Argonautes direct transcriptome surveillance within peri-nuclear membraneless organelles called nuage. In C. elegans, a family of Vasa-related Germ Line Helicase (GLH) proteins localize in, and promote the formation of nuage called P granules. Previous studies have implicated GLH proteins i...
ORGANISM(S): Caenorhabditis elegans 
2022-03-10 | GSE198101 | GEO
GenomicsA family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing
Germline Argonautes direct transcriptome surveillance within peri-nuclear membraneless organelles called nuage. In C. elegans, a family of Vasa-related Germ Line Helicase (GLH) proteins localize in, and promote the formation of nuage called P granules. Previous studies have implicated GLH proteins i...
ORGANISM(S): Caenorhabditis elegans 
2022-01-30 | GSE195536 | GEO
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