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UnknownFructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.
Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated the impact of fructose malabsorption on intestinal endocrine function and addressed the role of the microbiota in this process. To answer this question, a mouse model of moderate fructose ...
S-EPMC6988857 | biostudies-literature
UnknownBonding and the role of electrostatics in driving C-C bond formation in high valent organocopper compounds.
The electronic structures and contrasting reactivity of [Cu(CF3)4]- and [Cu(CF3)3(CH3)]- were probed using coupled cluster and ab initio valence bond calculations. The Cu-C bonds in these complexes were found to be c...
S-EPMC10173383 | biostudies-literature
UnknownHepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.
The Ron receptor is deregulated in a variety of cancers. Hepatocyte growth factor-like protein (HGFL) is the ligand for Ron and is constitutively secreted from hepatocytes into the circulation. While a few recent reports have emerged analyzing ectopic HGFL overexpression of in cancer cells, no studi...
S-EPMC4170603 | biostudies-literature
UnknownOn the Mechanism of Ezrin Activation.
Ezrin is a peripheral membrane protein that contributes to the organization and stability of cellular membrane structures by reversibly linking the plasma membrane to actin filaments. The formation of this membrane-actin linkage has been experimentally shown to require ezrin N-terminal (FERM) domain...
S-EPMC12637478 | biostudies-literature
UnknownProstate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression.
Effective treatment of advanced prostate cancer persists as a significant clinical need as only 30% of patients with distant disease survive to 5 years after diagnosis. Targeting signaling and tumor cell-immune cell interactions in the tumor microenvironment has led to the development of powerful im...
S-EPMC7415572 | biostudies-literature
UnknownThe Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer.
Multiple growth pathways lead to enhanced proliferation in malignant cells. However, how the core machinery of DNA replication is regulated by growth signaling remains largely unclear. The sliding clamp proliferating cell nuclear antigen (PCNA) is an indispensable component of the DNA machinery resp...
S-EPMC4064789 | biostudies-literature
UnknownPostvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD.

Background

The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown.

Methods

We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD.

Results

The study group included ...
S-EPMC9452161 | biostudies-literature
UnknownNatural variation in stochastic photoreceptor specification and color preference in Drosophila.
Each individual perceives the world in a unique way, but little is known about the genetic basis of variation in sensory perception. In the fly eye, the random mosaic of color-detecting R7 photoreceptor subtypes is determined by stochastic on/off expression of the transcription factor Spineless (Ss)...
S-EPMC5745083 | biostudies-literature
UnknownCrohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome.

Background

Crohn's disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and their relationship to disease phenoty...
S-EPMC9377146 | biostudies-literature
UnknownCombination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease.

Background

Mutations in the nucleotide oligomerization domain-2 (NOD2) gene and positive antibodies to microbial antigens have been found to be associated with the Crohn's disease (CD) phenotype, fibrostenosis. The aim of this study was to confirm these relationships in a large cohort of CD ...
S-EPMC3875376 | biostudies-literature
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