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TranscriptomicsSpliceosome-Mediated-Decay (SMD) regulates expression of non-intronic genes in budding yeast
Purpose: The goals of this study were to determine whether the spliceosome interacts with non-intronic mRNAs Methods: RNAseq was performed on RNA that immunoprecipitated with the yeast SMD1 protein. Tandem-affinity-purified RNAs were extracted and RNAseq libraries were generated using the EpiCentre...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-11 | E-GEOD-49966 | biostudies-arrayexpress
ProteomicsDSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts
The timely termination of RNA polymerase II (Pol II) transcription is essential for recycling of this enzyme and preventing transcriptional interference. While 5'-3' exonuclease Xrn2 is known to degrade nascent RNA after poly(A) site cleavage to promote Pol II release, its molecular mechanism remain...
ORGANISM(S): Schizosaccharomyces pombe 
2024-11-22 | PXD058168 | Pride
Xrn2 Ms-ms Spt5 Torpedo Fission yeast (schizosaccharomyces pombe) Dsif Crosslinking 
ProteomicsSystem-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organisation and function of RNA-protein complexes
Production, function, and turnover of mRNA are orchestrated by multi-subunit machineries that play a central role in gene expression. Within these molecular machines, interactions with the target mRNA are mediated by RNA-binding proteins (RBPs), and the accuracy and dynamics of these RNA-protein int...
ORGANISM(S): Schizosaccharomyces pombe OY26 
2021-09-09 | PXD016741 | Pride
Rna exosome complex  rna interactome capture  rna-binding proteins  rna-protein crosslinking  ribonucleoprotein complexes 
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