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ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-07 | PXD014290 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
ProteomicsTwo distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the PRC2 core associates with distinct ancillary subunits such as...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-22 | PXD020684 | Pride
Chromatin Prc2 Embryonic stem cells Polycomb 
ProteomicsMtf2 is a methylation-sensitive DNA-binding recruiter of Polycomb
Polycomb repression of gene expression is critical for development, with a pivotal role for trimethylation of lysine 27 of histone H3 (H3K27me3) deposited by Polycomb Repressive Complex 2 (PRC2). While the function and regulation of PRC2 have been extensively studied, the mechanism(s) by which it is...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-07 | PXD005821 | Pride
Mtf2 Embryonic stem cells Prc2 Polycomb 
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