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TranscriptomicsTranscriptional profiling of normal and JAK2V617F-positive erythroblasts of polycythemia vera and essential thrombocythemia
This experiment was designed to identify genes differentially expressed in association with the JAK2V617F mutation in polycythemia vera (PV) and essential thrombocythemia (ET). Peripheral blood was obtained from 20 ET and 16 PV patients and erythroid progenitors were grown in semi-solid methylcellul...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-MTAB-384 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Aloe vera transcriptome using the Affymetrix ATH1 GenChip
The Aloe vera transcriptome was analysed by hybridising triplicate samples of root and leaf tissue to the Affymetrix Arabidopsis ATH1 array. In total, 7 samples were hybridised to the array. Samples consisted of 1 genomic DNA, and triplicate samples of leaf and root RNA.
ORGANISM(S): Aloe vera 
2011-03-26 | E-GEOD-24389 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Polycythemia Vera (PV)
To define the molecular abnormalities at the stem cell level in polycythemia vera (PV), we examined global gene expression in circulating CD34+ cells from 19 JAK2 V617F-positive PV patients and 6 normal individuals using Affymetrix oligonucleotide microarray technology. We observed that CD34+ cell g...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-47018 | biostudies-arrayexpress
ProteomicsProteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by hyper-proliferation of the erythroid, megakaryocytic and granulocytic lineages and the presence of an activating mutation in JAK2. To elucidate mechanisms that regulate PV stem cells, we applied a newly developed data-ind...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD021178 | Pride
Human Polycythemia vera Hematopoietic stem and progenitor cell subpopulations 
ProteomicsInvestigating the proteome of red blood cells and reticulocytes in Polycythemia Vera and Essential Thrombocythemia
The project aims at comparing the effect of the JAK2V617F mutation on protein expression in human erythroid cells in the context of Polycythemia Vera and Essential Thrombocythemia
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029965 | Pride
Reticulocytes Human red blood cells Erythrocytes Polycythemia vera Nlc-ms/ms Orbitrap fusion Essential thrombocythemia Jak2v617f 
ProteomicsTargeting Fibrotic Scars with Extracellular Vesicles Extracted from Mature Aloe vera: Enhanced Antioxidant, Anti-inflammatory, and Antifibrotic Activity through M2 Macrophage Polarization and Myofibroblasts Inhibition.
This study aimed to isolate and characterize Av-EVs and evaluate their antioxidant, anti-inflammatory, and antifibrotic properties in vitro, focusing on the impact of extraction method and plant maturity.
ORGANISM(S): Aloe vera 
2026-05-25 | PXD069742 | Pride
Inflammation resolution Myofibroblast differentiation Wound healing Oxidative stress Regenerative skin therapy. 
TranscriptomicsAberrant DNA methylation profiling of classic Philadelphia Negative Myeloproliferative Neoplasms
Since most DNA methylation studies in Classic Philadelphia-negative myeloproliferative neoplasms (MPNs) M-bM-^@M-^S polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) - have been performed on a gene-by-gene basis, a more comprehensive methylation profiling is n...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-42042 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Kawasaki disease patients who may benefit from methylprednisolone
Clinical score and transcript abundance patterns identify Kawasaki disease patients who may benefit from addition of methylprednisolone. Intravenous immunoglobulin (IVIG) treatment-resistant patients are high risk of developing coronary artery lesions (CALs) with Kawasaki disease (KD). The IVIG-resp...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-16797 | biostudies-arrayexpress
UnknownSelf-(in)compatibility in apricot germplasm is controlled by two major loci, S and M.
Not available
S-EPMC5405505 | biostudies-literature
Unknownm.3685T > C is a novel mitochondrial DNA variant that causes Leigh syndrome.
Not available
S-EPMC8958915 | biostudies-literature
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