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ProteomicsImmunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes
Listeria monocytogenes is a foodborne intracellular bacterial pathogen leading to human listeriosis. Despite a high mortality rate and increasing antibiotic resistance no clinically approved vaccine against Listeria is available. To identify antigens for this bacterial pathogen that can be encoded i...
ORGANISM(S): Homo sapiens (Human) Listeria monocytogenes EGD 
2022-09-26 | PXD031451 | Pride
Tmt Fusion lumos Listeria monocytogenes Hela Immunopeptidomics Epitope discovery Bacterial infection Label-free Q exactive hf Hct-116 Antigen discovery Vaccine development 
ProteomicsImmunopeptidomics identification of Listeria monocytogenes T cell epitopes in mice
Listeria monocytogenes is a foodborne intracellular bacterial model pathogen. Protective immunity against Listeria depends on an effective CD8 T-cell responses, but very few T cell epitopes are known in mice as most common animal infection model for listeriosis. To identify epitopes we screened for ...
ORGANISM(S): Mus musculus (Mouse) Listeria monocytogenes 
2024-08-13 | PXD047750 | Pride
Mhc Listeria monocytogenes T-cell epitopes Immunopeptidomics Mouse 
ProteomicsExploring omics-identified antigens and mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide for multiple myeloma therapy
Introduction: Natural killer T (NKT) cells and CD8+ T cells are key in the immune response against multiple myeloma (MM), a largely incurable blood cancer. Immunization is a promising strategy to activate these T cell populations. To our knowledge, immunization with mRNA and α-galactosyl ceramide (α...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD060156 | Pride
Cancer Myeloma Mouse Immunopeptidomics 
UnknownComprehensive molecular characterization of mitochondrial genomes in human cancers.
Not available
S-EPMC7058535 | biostudies-literature
UnknownCancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.
Not available
S-EPMC7002399 | biostudies-literature
UnknownReconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Not available
S-EPMC7002414 | biostudies-literature
UnknownIntegrative pathway enrichment analysis of multivariate omics data.
Not available
S-EPMC7002665 | biostudies-literature
UnknownComprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.
Not available
S-EPMC7058534 | biostudies-literature
UnknownInferring structural variant cancer cell fraction.
Not available
S-EPMC7002525 | biostudies-literature
UnknownDisruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
Not available
S-EPMC7058537 | biostudies-literature
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