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ProteomicsInhibition of choline metabolism in an angioimmunoblastic T cell lymphoma preclinical model reveals a new treatment option
Background: Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in need of new more specific therapeutic regimen. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh). The metabolism of these malignant Tfh cells was not yet elucida...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-04 | PXD046786 | Pride
Choline kinase Choline Aitl Lipid metabolism Cdp-ethanolamine pathway T cell lymphoma Cdp-choline pathway Cancer therapy 
TranscriptomicsThe TCR activation acts as a tumor suppressor mechanism in T-ALL
Developmental checkpoints in stem/progenitor cells are critical to the determination, commitment and differentiation into distinct lineages. Cancer cells often retain expression of lineage-specific checkpoint proteins, but their potential impact in cancer remains elusive. T lymphocytes mature in the...
ORGANISM(S): Homo sapiens 
2016-08-20 | E-GEOD-65496 | biostudies-arrayexpress
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