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UnknownInvestigation of dual-bend serpentine/spiral waveguides coupled to a microchannel system for competent, evanescent-wave-absorption-based, on-chip, biological-/chemical-sensing applications.
Not available
S-EPMC9088425 | biostudies-literature
TranscriptomicsDNA methylation in normal PC, MGUS, SMM and MM
To characterize epigenomic changes during the transformation of normal plasma cells to myeloma, we used the HELP assay to analyze the methylome of CD138+ cells from 56 subjects representing premalignant (MGUS), early and advanced stages of myeloma as well as healthy controls. Plasma cells from prem...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43860 | biostudies-arrayexpress
UnknownCost-effective smart microfluidic device with immobilized silver nanoparticles and embedded UV-light sources for synergistic water disinfection effects.
Not available
S-EPMC9122560 | biostudies-literature
TranscriptomicsA restricted repertoire of cytosine methylation changes in neonates following intrauterine growth restriction
Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g. type 2 diabetes mellitus; T2DM), manifesting sometimes decades later. We hypothesized that this biological memo...
ORGANISM(S): Homo sapiens 
2010-02-17 | E-GEOD-17727 | biostudies-arrayexpress
GenomicsAltered patterns of hydroxymethylation regulate oncogenic pathways in pancreatic cancer
Transcriptional deregulation of oncogenic pathways is a hallmark of cancer, and can be due to epigenetic alterations. 5-hydroxymethylcytosine is a recently discovered epigenetic modification that has not been studied in pancreatic cancer. Genome-wide analysis of 5-hmC enriched loci was conducted in ...
ORGANISM(S): Homo sapiens 
2016-08-06 | E-GEOD-71839 | biostudies-arrayexpress
TranscriptomicsAnalysis of DNA methylation changes in normal human hematopoietic stem and progenitor cells
DNA methylation analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using HELP arrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in ...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52151 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Chronic kidney disease
Epidemiological studies indicate that adverse intrauterine and postnatal environment has a long-lasting role in chronic kidney disease (CKD) development. Epigenetic information can represent a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine meth...
ORGANISM(S): Homo sapiens 
2013-07-18 | E-GEOD-48944 | biostudies-arrayexpress
UnknownMicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis.
Not available
S-EPMC11868536 | biostudies-literature
TranscriptomicsGenome-wide DNA Methylation Analysis Reveals Novel Targets for Drug Development in Mantle Cell Lymphoma
Mantle Cell Lymphoma (MCL) is a mostly incurable malignancy arising from naïve B cells (NBC) in the mantle zone of lymph node follicles. We analyzed genome-wide methylation in MCL patients using the HELP (Hpa II tiny fragment Enrichment by Ligation mediated PCR) assay and found significant aberrancy...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-19243 | biostudies-arrayexpress
TranscriptomicsAnalysis of RNA expression changes in normal human hematopoietic stem and progenitor cells
RNA expression analysis on purified human long-term and short-term hematopoietic stem cells (LT-HSC, ST-HSC), common myeloid and megakaryocyte-erythrocyte progenitor cells (CMP, MEP) using microarrays. FACS-purified hematopoietic stem and progenitor cell (HSPC) subsets were analyzed for changes in R...
ORGANISM(S): Homo sapiens 
2014-02-07 | E-GEOD-52150 | biostudies-arrayexpress
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