A restricted repertoire of cytosine methylation changes in neonates following intrauterine growth restriction

ABSTRACT: Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g. type 2 diabetes mellitus; T2DM), manifesting sometimes decades later. We hypothesized that this biological memory is mediated by permanent alterations of the epigenome in stem cell populations. Our studies focused specifically on DNA methylation in CD34+ hematopoietic stem and progenitor cells from cord blood, and utilized a two-stage design involving genome-wide discovery followed by quantitative, single-locus validation. We found that changes in cytosine methylation occur in response to intrauterine growth restriction (IUGR), but that they are of a substantially lesser degree and involve many fewer l

ORGANISM(S): Homo sapiens

SUBMITTER: Amit Verma 

PROVIDER: E-GEOD-17727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress