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UnknownNucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction.
Not available
S-EPMC1097768 | biostudies-literature
UnknownConformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket.
Not available
S-EPMC6001276 | biostudies-literature
ProteomicsDomain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating its tumor suppressive functions, and by conferring aberrant pro-carcinogenic activities. We report here that mis-sense mutants in the p53 DNA-binding domain (DBD) and the transactivation domain (TAD) unexpectedly activate...
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD031725 | JPOST Repository
UnknownMolecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.
Not available
S-EPMC5981469 | biostudies-literature
UnknownHydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.
Not available
S-EPMC5431542 | biostudies-literature
ProteomicsHDX-MS of CHIP wt and K30A mutant
HDX-MS was used to establish that conformational-inhibition-signals extended from the TPR-domain to the U-box of CHIP. This underscores inter-domain allosteric regulation of CHIP by the core molecular chaperones. Defining the chaperone-associated TPR-domain of CHIP as a manager of inter-domain commu...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-07-30 | MSV000079205 | MassIVE
UnknownStitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein.
Not available
S-EPMC10685803 | biostudies-literature
ProteomicsSalmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth
Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called Salmonella-containing vacuoles (SCVs) and avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how l...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD055151 | Pride
Salmonella typhimurium Cholesterol Arf1 activation Peroxisome targeting sequence Peroxisomes 
ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
UnknownPopulation deworming every 6 months with albendazole in 1 million pre-school children in North India: DEVTA, a cluster-randomised trial.
Not available
S-EPMC3647147 | biostudies-literature
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