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TranscriptomicsNon-coding transcription within the Igh distal VH region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells
Non-coding sense and antisense germline transcription within the immunoglobulin heavy chain locus precedes V(D)J recombination and has been proposed to be associated with Igh locus accessibility, although its precise role remains elusive. However, no global analysis of germline transcription through...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-40984 | biostudies-arrayexpress
GenomicsChIP-seq analysis of CTCF binding sites in lymphocyte subsets [DN thymocytes]
In this study, we compare the binding pattern of CTCF at the T cell receptor alpha locus in different subsets of developing lymphocytes. For the ChIP-seq, input and immunoprecipitated DNA was given to The Scripps DNA Array Facility, where it was prepared for massively parallel sequencing on Illumin...
ORGANISM(S): Mus musculus 
2012-12-03 | E-GEOD-41739 | biostudies-arrayexpress
GenomicsChIP-seq analysis of CTCF binding sites in lymphocyte subsets [pro-B cells]
In this study, we compare the binding pattern of CTCF at the T cell receptor alpha locus in different subsets of developing lymphocytes For the ChIP-seq, input and immunoprecipitated DNA was given to The Scripps DNA Array Facility, where it was prepared for massively parallel sequencing on Illumina...
ORGANISM(S): Mus musculus 
2012-12-03 | E-GEOD-41741 | biostudies-arrayexpress
GenomicsChIP-seq analysis of CTCF binding sites in lymphocyte subsets
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-03 | E-GEOD-41743 | biostudies-arrayexpress
GenomicsChIP-seq analysis of CTCF binding sites in lymphocyte subsets [DP thymocytes]
In this study, we compare the binding pattern of CTCF at the T cell receptor alpha locus in different subsets of developing lymphocytes For the ChIP-seq, input and immunoprecipitated DNA was given to The Scripps DNA Array Facility, where it was prepared for massively parallel sequencing on Illumina...
ORGANISM(S): Mus musculus 
2012-12-03 | E-GEOD-41740 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profile of antigen receptor activated B cells
To search for rapid changes in gene expression following BCR activation, we performed DNA microarray analysis of activated splenic B cells with and without anti-IgM treatment for 3 hour. The expression of a remarkably large set of genes differed significantly. Primary B-lymphocytes were purified fro...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15606 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profile of antigen receptor activated B cells expressing wildtype or Calmodulin (CaM) - resistant E12
To elucidate the genome-wide role of Ca2+/ calmodulin inhibition of E2A in regulation of BCR activation, we performed DNA microarray analysis of activated splenic B cells expressing wildtype or CaM-resistant E12 mutant m8N47 with and without anti-IgM treatment for 3 hour.The expression of a remarkab...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-35747 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profile showing early changes in gene expression in antigen receptor activated B cells
To search for rapid changes in gene expression following BCR activation, we performed DNA microarray analysis of activated splenic B cells with and without anti-IgM treatment for 1 and 2 hour. Primary B-lymphocytes were purified from mouse spleens and stimulated with IL-4 (Pepro-Tech) and CD40L (R&D...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-35748 | biostudies-arrayexpress
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