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To investigate whether and to which extent the gene expression changes in DNA repair deficient mice (i.e. Csbm/m/Xpa-/- and Ercc1-/-) overlap with those observed in a natural aged liver, we sought to compare the full mouse liver transcriptome of adult 16-, 96- and 130-week old wt C57Bl/6J mice (n=4)...
ORGANISM(S): Mus musculus 
We demonstrate that transcriptomic profiling of the NER mutant ercc-1 offers better understanding of the complex phenotypes of ercc-1 deficiency in C. elegans, as it does in mammalian models. There is a transcriptomic shift in ercc-1 mutants that suggests a stochastic impairment of growth and develo...
ORGANISM(S): Caenorhabditis elegans 
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