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TranscriptomicsExpression data from Versican (VCAN) protein treated ovarian cancer cell line OVCA433
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40241 | biostudies-arrayexpress
ProteomicsVersican regulating viscoelasticity drives pleural fibrosis via mechanotransductive signaling
Extracellular matrix (ECM) disorder was considered as the result of fibrosis, but it is recently recognized that fibrotic ECM activates a profibrotic positive feedback loop and contributes to development of fibrosis. Versican, an ECM component, participates in cell-ECM interaction and ECM regenerati...
ORGANISM(S): Homo Sapiens 
2026-01-15 | PXD073100 |
GenomicsMolecular Characterization of auditory nerve with Versican deficiency
Molecular Characterization of auditory nerve with Versican deficiency
PRJNA503256 | ENA
ProteomicsVersican in murine cell line supernatants
The tumor derived Versican (VCAN) can be a possible mediator of the host NF-κB pathway in cancer pathogenesis. In this context, we defined VCAN function in the pathogenesis development in vitro with cell lines as well as in vivo with mouse model. We used the proteomic technique to quantify VCAN inte...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD019883 | Pride
Vcan  versican  mouse  cancer  cell line 
ProteomicsIdentification of novel ADAMTS cleavage sites in versican using a label-free quantitative proteomics approach
We used recombinant Versican (either isoform V1 or an abridged isoform called V1-5GAG) digested with purified ADAMTS1, 4, or 5 compared to inactive controls to determine novel protease cleavage sites within versican.
ORGANISM(S): Homo sapiens (Human) 
2022-09-23 | PXD025456 | Pride
Versican Z-score Adamts 
TranscriptomicsSharpin promotes hepatocellular carcinoma progression via transactivation of versican expression
Sharpin (Shank-associated RH domain-interacting protein, also known as SIPL1) is a multifunctional molecule that participates in various biological settings, including nuclear factor-κB signaling activation and tumor suppressor gene inhibition. Sharpin is upregulated in various types of cancers, inc...
ORGANISM(S): Homo sapiens 
2017-01-23 | GSE87149 | GEO
GenomicsSingle-cell RNA sequencing of Versican (Vcan) knockout mice after cardiac ischemia.
Single-cell RNA sequencing of Versican (Vcan) knockout mice after cardiac ischemia.
PRJEB61792 | ENA
UnknownPlasma versican and plasma exosomal versican as potential diagnostic markers for non-small cell lung cancer.
Not available
S-EPMC10230736 | biostudies-literature
UnknownVersican degradation and vascular disease.
Not available
S-EPMC3169384 | biostudies-literature
UnknownVersican mediates mesenchymal-epithelial transition.
Not available
S-EPMC1415306 | biostudies-literature
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