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ProteomicsModic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates
Abstract Background Vertebral endplate signal intensity changes visualized by magnetic resonance imaging termed Modic changes (MC) are highly prevalent in low back pain patients. Interconvertibility between the three MC subtypes (MC1, MC2, MC3) suggests different pathological stages. Histologically,...
ORGANISM(S): Homo sapiens (Human) 
2025-03-21 | PXD038008 | Pride
Complement system Label free quantification Inflammation Human Angiogenesis Evosep Fibrosis Timstof Modic type 2 changes Neurogenesis Vertebral endplates 
UnknownThe impact of age on the morphology of the 12th thoracic vertebral endplates.
Not available
S-EPMC9747336 | biostudies-literature
Genomics
GDF15 induces excessive activation of osteoclasts within the vertebral endplates leading to early endplate degeneration
PRJNA1328439 | ENA
UnknownModic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates.
Not available
S-EPMC10041382 | biostudies-literature
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S-EPMC5983445 | biostudies-literature
UnknownPGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib.
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S-EPMC8326284 | biostudies-literature
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Not available
S-EPMC12500679 | biostudies-literature
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