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MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
TranscriptomicsCandidate prostate cancer genes through comparative expression-profiling of seminal vesicle
BACKGROUND: Prostate cancer is the most frequently diagnosed cancer among men in the United States. In contrast, cancer of the seminal vesicle is exceedingly rare, despite that the prostate and seminal vesicle share similar histology, secretory function, androgen dependency, blood supply, and (in p...
ORGANISM(S): Homo sapiens 
2008-05-08 | E-GEOD-11376 | biostudies-arrayexpress
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Aedes infected with alphavirus, Sindbis (MRE16 Malaysian strain)
The midgut of hematophagous insects is the initial site of infection by arthropod-borne viruses (arboviruses) and plays a crucial role in vector competence. To further understand processes that occur in the midgut in response to infection by an arbovirus, DNA microarrays were used to analyze gene ex...
ORGANISM(S): Aedes aegypti 
2005-08-01 | E-MEXP-381 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis cell-sorted, hydrated pollen grains vs those of flowers, leaves, seedlings and siliques
Upon germination, pollen forms a tube that elongates dramatically through female tissues in order to reach and fertilize ovules. While essential for the life cycle of higher plants, the genetic basis underlying most of the process is not well understood. We used Affymetrix Arabidopsis ATH1 Genome Ar...
ORGANISM(S): Arabidopsis thaliana 
2005-06-01 | E-MEXP-285 | biostudies-arrayexpress
ProteomicsRab10-CAV1 mediated intraluminal vesicles transport to migrasomes
Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The content cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal comp...
ORGANISM(S): Mus Musculus 
2024-05-23 | PXD046146 |
UnknownPropofol attenuates kinesin-mediated axonal vesicle transport and fusion.
Not available
S-EPMC9634964 | biostudies-literature
TranscriptomicsTrancription profiling of the hepatoma cell line Huh7 infected with the Hepatitis C Virus
Hepatitis C Virus is a leading cause of chronic liver disease. The identification and characterisation of key host cellular factors that play a role in the HCV replication cycle is important for the understanding of disease pathogenesis and the identification of novel anti-viral therapeutic targets....
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-20948 | biostudies-arrayexpress
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