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ProteomicsStructure of Tau filaments in Prion protein amyloidoses
In human neurodegenerative diseases associated with the intracellular aggregation of Tau protein, the ordered cores of Tau filaments adopt distinct folds. Here, we analyze Tau filaments isolated from the brain of individuals affected by Prion-Protein cerebral amyloid angiopathy (PrP-CAA) and Gerstma...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025663 | Pride
Brain Tau Gss Prp-caa Cryo-em Seeding Aprp Neurodegeneration 
ProteomicsCross-Beta Helical Fibrils of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with Presenile Dementia
Neurodegenerative diseases characterized by tau aggregates have distinct tau pathological profiles that may differ in relation to the morphology and structure of the filaments, the tau-isoform composition and the cell types and brain areas that are affected. Neurons, dendrites and axonal terminals a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-06 | MSV000090845 | MassIVE
ProteomicsDistinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72)
Frontotemporal dementias are neuropathologically characterized by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathologic hallmark of approximately half of the FTLD cases, being referred to as FTLD-TDP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-12 | MSV000089242 | MassIVE
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S-EPMC7894852 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
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S-EPMC12303861 | biostudies-literature
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
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S-EPMC7995808 | biostudies-literature
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S-EPMC8206995 | biostudies-literature
UnknownSARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.
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S-EPMC8652887 | biostudies-literature
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