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TranscriptomicsTranscription profiling of human HMEC after stimulation with MRP8/MRP14
GEnerating the the gene expression profil of MRP8/MRP14-stimulated HMEC monolayer. Experiment Overall Design: 4 independent experiments Experiment Overall Design: HMEC-1 monolayer were left untreated or stimulated for 6h with 200 µg/ml MRP8/MRP14.
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human umbilical vein endothelial cells (HUVEC) stimulated with TNF vs. controls reveals TNF induces distinct expression programs
HUVEC were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparsion of the gene profiles revealed TNF-mediated gene expression changes in HUVEC.
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-2639 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human mammary epithelial cells (HMEC) stimulated with TNF vs. controls reveals TNF induces distinct expression programs
HMEC cultures were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparison of the gene expression profiles revealed the TNF-mediated gene expression changes.
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-2638 | biostudies-arrayexpress
TranscriptomicsFoxO3 modulates endothelial gene expression and function by direct and indirect mechanisms
FoxO transcription factors represent targets of the PI3K/PKB survival pathway controlling important biological processes such as stress responses, cell cycle progression, apoptosis, vascular remodelling and metabolism. Recent studies have demonstrated the existence of alternative mechanisms of FoxO-...
ORGANISM(S): Homo sapiens 
2010-01-31 | E-GEOD-16573 | biostudies-arrayexpress
TranscriptomicsHighly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages
Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a ...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-27702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of HUVEC infected with Influenza virus
To delineate specific patterns of signaling networks activated by H5N1 we used a comparative systems biology approach analyzing gene expression in endothelial cells infected with three different human and avian influenza strains of high and low pathogenicity. HUVECs were infected with either PR8, F...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-13637 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC cells infected with Candida
Using oligonucleotide microarray analysis, we identified 56 genes that were transcriptionally up-regulated and 69 that were suppressed upon exposure of endothelial cells to C. albicans. Among the regulated genes those attributed to the categories ‘chemotaxis’, ‘signaling’, and ‘transcripti...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7355 | biostudies-arrayexpress
TranscriptomicsHighly pathogenic influenza virus inhibit Inflammatory Responses in Monocytes via Activation of the Rar-Related Orphan Receptor Alpha (RORalpa)
Highly pathogenic influenza virus inhibit Inflammatory Responses in Monocytes via Activation of the Rar-Related Orphan Receptor Alpha (RORalpha). Low (PR8) and high pathogenic influenza viruses (FPV and H5N1) were used. Monocytes were infected with low (PR8) and high pathogenic influenza viruses (FP...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-35283 | biostudies-arrayexpress
TranscriptomicsSignaling pathways of HPAIV
Highly pathogenic avian influenza viruses (HPAIV) induce severe inflammation in poultry and men. There is still an ongoing threat that these viruses may acquire the capability to freely spread as novel pandemic virus strains that may cause major morbidity and mortality. One characteristic of HPAIV i...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-40281 | biostudies-arrayexpress
TranscriptomicsPostnatal monocyte maturation requires age-dependent initiation of regulatory gene programs when losing birth-associated stress tolerance
We disprove that the impaired Myd88-dependent proinflammatory response of neonatal monocytes is a correlate for immaturity and confirm it as display of transient alarmin-mediated stress tolerization. We find a strong inducibility of TRIF-dependent genes in neonatal monocytes by LPS but a barely dete...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-78697 | biostudies-arrayexpress
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