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MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
MetabolomicsMetabolomics identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis
Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal flui...
2018-01-24 | MTBLS413 | MetaboLights
UnknownQuantum chemical insight into the effects of the local electron environment on T2*-based MRI.
Not available
S-EPMC8531323 | biostudies-literature
MetabolomicsMetabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory stimuli either alone or in combination on macropha...
2018-03-13 | MTBLS570 | MetaboLights
UnknownSeasonal variation and temporal relationship to the COVID-19 pandemic of NMDA receptor antibody results.
Not available
S-EPMC10576721 | biostudies-literature
GenomicsMapping Novel Chromatin Regions Using Sono-Seq
We found that sonication of crosslinked chromatin produces breaks at non-random sites in DNA and can be used to map sites of high chromatin accessibility when combined with high-throughput tag sequencing using the GA II platform from Illumina. This technique, which we named Sono-Seq, can be a simple...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-14022 | biostudies-arrayexpress
ProteomicsMITOMICS: defining mitochondrial protein functions through deep multi-omic profiling
Mitochondria are epicenters of eukaryotic metabolism and bioenergetics. Pioneering efforts in recent decades have established the core protein componentry of these organelles and have linked their dysfunction to over 150 distinct disorders. However, hundreds of mitochondrial proteins still lack clea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-11 | MSV000086685 | MassIVE
ProteomicsA novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins
Recent developments in affinity binder or mass spectrometry (MS)-based plasma proteomics are now producing panels of potential biomarker candidates for diagnosis or prognosis. However, clinical validation and implementation of these biomarkers remain limited by the reliance on dated triple quadrupol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095051 | MassIVE
UnknownA novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change of C-reactive protein
Not available
S-SCDT-10_15252-EMMM_202216236 | biostudies-other
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