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TranscriptomicsRNA-seq of human intestinal organoids colonized with E. coli and other immature intestinal tissues
We performed RNA-seq to demonstrate that the epithelium of human pluripotent stem cell-derived human intestinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investigate complex host-microbe interactions in this naive epithelium. RNA was isolated using the mir...
ORGANISM(S): Homo sapiens 
2017-09-01 | E-MTAB-5801 | biostudies-arrayexpress
UnknownHeart failure hospitalizations and clinical outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair: Insights from EuroTR.
Not available
S-EPMC12482852 | biostudies-literature
GenomicsSenataxin resolves R-loops forming at DNA double strand breaks to prevent translocations
DNA Double Strands Breaks (DSBs) are highly detrimental since they can lead to mutations and chromosomes rearrangements (amplification, deletion, translocation and chromosome loss). Here, we set to assess the role of senataxin, a RNA:DNA helicase involved in the regulation of transcription and the m...
ORGANISM(S): Homo sapiens 
2018-02-20 | E-MTAB-6318 | biostudies-arrayexpress
TranscriptomicsChromatin compartmentalization regulates the response to DNA damage
DNA Double Strand Breaks (DSBs) repair is essential to safeguard genome integrity but little is known about the contribution of chromosome folding into these processes. Here we unveiled basic principles of chromosome dynamics occurring post-DSB both locally and at a genome wide scale in mammalian ce...
ORGANISM(S): Homo sapiens 
2023-11-17 | E-MTAB-10865 | biostudies-arrayexpress
TranscriptomicsSmoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2
Rationale: Genome-wide association studies (GWAS) and candidate gene studies have identified a number of loci linked to susceptibility of chronic obstructive pulmonary disease (COPD), a smoking-related disorder that originates in the airway epithelium. Objectives: Since airway basal cell (BC) stem/p...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-47718 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of the secretome from human myotube and myotube derived vesicles
Human satellite cells were isolated from muscle biopsies and expanded in vitro. Cells were induced to differentiate into branched multinucleated myotubes by serum depletion and were harvested from three independent cultures after 72 hours. Total RNA was isolated, amplified, labelled and hybridised...
ORGANISM(S): Homo sapiens 
2011-04-30 | E-MTAB-423 | biostudies-arrayexpress
TranscriptomicsConcordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study
Background: Genome-wide transcriptome profiling generated by microarray and RNA-Seq often provides deregulated genes or pathways applicable only to larger cohort. On the other hand, individualized interpretation of transcriptomes is increasely pursued to improve diagnosis, prognosis, and patient tre...
ORGANISM(S): Homo sapiens 
2013-11-20 | E-GEOD-52493 | biostudies-arrayexpress
TranscriptomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
2025-11-12 | E-MTAB-12712 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics data from the lungNENomics cohort of lung neuroendocrine tumours
This dataset contains spatial transcriptomics data of four lung neuroendocrine tumours (lung NETs), a rare and understudied type of lung cancer. The dataset consists of raw sequencing data, metadata, and gene expression matrices. It is part of the lungNENomics project. See https://doi.org/10.5281/z...
ORGANISM(S): Homo sapiens 
2026-05-22 | E-MTAB-17055 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of indole-3-acetic acid at physiological concentrations (IAA) treatment of Arabidopsis seedlings
To demonstrate the analysis of differential expression using CATMA v1 arrays, Arabidopsis seedlings were treated with indole-3-acetic acid at physiological concentrations. The seedlings were germinated in liquid medium, and treated with indole-3-acetic acid for 30, 120 or 240 minutes. Changes in exp...
ORGANISM(S): Arabidopsis thaliana 
2004-05-31 | E-MEXP-65 | biostudies-arrayexpress
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