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MetabolomicsControlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture on viral replication is insufficiently understood. Single cell transcriptomics applying vesi...
2025-06-24 | MTBLS12437 | MetaboLights
MetabolomicsUntargeted metabolomics reveals bovine viral diarrhea virus infection reprogram host nucleotide and amino acid metabolism in MDBK Cells

Bovine viral diarrhea virus (BVDV) is a highly adapted intracellular parasite that depends entirely on the host cell's metabolic resources and energy for the synthesis of viral components. However, the mechanisms by which BVDV remodels host lipid metabolism remain unclear. In this study, we explo...

2025-10-12 | MTBLS13126 | MetaboLights
MetabolomicsBrain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoids (CBOs) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found t...
2026-06-18 | MTBLS14790 | MetaboLights
ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
TranscriptomicsEgress of mature murine regulatory T cells from the thymus requires RelA
The mechanism of egress of mature regulatory T cells (Tregs) from the thymus to the periphery remains enigmatic, as does the nature of those factors expressed in the thymic environment. Here, we examined the fate of thymic Tregs in TNFα/RelA double-knockout (TA-KO) mice, because TA-KO mice retain a...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-64191 | biostudies-arrayexpress
ProteomicsNovel asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus
How essential asymmetries are built into icosahedral virus to facilitate directional genome egress is unknown. Here we capture the structure and dynamics of disassembly intermediates of an icosahedral virus. We reveal localized RNA density poised for release beneath 5-fold axes on one half of the vi...
ORGANISM(S): Turnip crinkle virus 
2025-11-06 | PXD067878 | Pride
Turnip crinkle virus Hdxms Rna egress Asymmetry Isopeptide bond 
TranscriptomicsmicroRNA-mediated GALNT3 upregulation facilitates mucin production and viral replication in influenza A virus-infected respiratory epithelial cells
Viral infections affecting the upper or lower respiratory tract induce mucin production in the epithelial surfaces of the respiratory cells. However, a little is known about how mucins are produced on the surfaces of respiratory epithelial cells and affects viral replication. In the course of the in...
ORGANISM(S): Homo sapiens 
2015-12-08 | E-GEOD-57508 | biostudies-arrayexpress
TranscriptomicsDifferentially-expressed miRNAs in MDBK cells infected with bovine viral diarrhea virus compared to MDBK cells
Non-canonical microRNAs (miRNAs) are a class of short endogenous RNA molecules with the ability to control development, autophagy, apoptosis and the stress response in eukaryotes by pairing with partially complementary sites in the 3' untranslated regions (UTRs) of targeted genes. Recent studies hav...
ORGANISM(S): Bos taurus 
2014-12-16 | E-GEOD-61251 | biostudies-arrayexpress
ProteomicsMyosin-9 is required for lysosome-mediated nonlytic reovirus egress
Mammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that assemble progeny particles in cytoplasmic viral factories (VFs) and exit some types of cells using a nonlytic release mechanism. In human brain microvascular endothelial cells (HBMECs), progeny reovirus virions...
ORGANISM(S): Homo sapiens (Human) Orthoreovirus 
2025-10-10 | PXD068971 | Pride
Reovirus  virus egress  myosin-9  proteomics  imaging 
UnknownHost and Viral Proteins Modulating Ebola and Marburg Virus Egress.
Not available
S-EPMC6357148 | biostudies-literature
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