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ProteomicsAssembly of cellular proteins with the HIV-1 genome into viral particles regulate virus production and infectivity
The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). However, the scope of these early host-virus interactions remain largely uncharecterised. To fill this gap, we developed in virion RNA interactome capture (ivRIC) to profi...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2026-05-25 | PXD042829 | Pride
Hiv  rna  rna-binding protein  virus infection  virion  viral particle  rev  rna-interactome capture  pura  purb 
ProteomicsGlobal analysis of the human cytomegalovirus interactome identifies degradation hubs, domain associations and viral protein functions
Human cytomegalovirus (HCMV) is an important pathogen that extensively modulates host cells, downregulating >900 human proteins over the course of viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins remains unresolved, and the fun...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) Betaherpesvirinae 
2020-01-22 | PXD014845 | Pride
Proteomics  systems virology  human cytomegalovirus  host-pathogen interaction  immune evasion  protein-protein interaction 
ProteomicsGlobal Interactome of ZIKV (FSS13025) viral proteins.
To identify the global cellular interactome of each ZIKV proteins, individual HA-tagged ZIKV proteins (FSS13025 Asian strain) were expressed in the neuroblastoma cell line SK-N-BE2 using lentivirus-mediated delivery. Cellular lysates were subjected to Affinity purification (AP) using HA-agarose bead...
ORGANISM(S): Homo sapiens (Human) Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013 
2018-09-03 | PXD009551 | Pride
Zikv Asian strain fss13025 Interactome Zika virus 
OtherThe functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Data from ProteomeXchange, PXD ID: PXD001572. File: 2012_07_03_IFIXGFP_PD13.mzml. Published as part of . From the Abstract: {{i}} he human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein intera...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310018443 | GPMDB
Resource Reanalysis 
ProteomicsA BioID-derived proximity interactome for SARS-CoV-2 proteins
The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral ther...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-18 | MSV000088245 | MassIVE
UnknownHuman cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.
Not available
S-EPMC6959991 | biostudies-literature
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
TranscriptomicsDetermination of the protein interactome of the transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors
Coordinate expression of the somatic cell reprogramming factors Oct4, Sox2, Klf4 and c-Myc within embryonic stem cells preserves the self-renewal of these cells, while allowing for the expression epitope tagged Sox2. Taking advantage of this observation, we engineered embryonic stem cells (i-OSKM-ES...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-34801 | biostudies-arrayexpress
ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD007634 | Pride
Proteomics Mass spectrometry Cullin ubiquitin ligases Ddb1 Viral interactome analysis 
ProteomicsGeneration and utilization of a monoclonal antibody against hepatitis B virus core protein for a comprehensive interactome analysis
Hepatitis B virus (HBV) core antigen (HBc) is a structural protein that forms the viral nucleocapsid and is involved in various steps of the viral replication cycle, but its role in the pathogenesis of HBV infection is still elusive. In this study, we generated a mouse monoclonal antibody against HB...
ORGANISM(S): Homo Sapiens (human) 
2023-02-21 | PXD036961 | JPOST Repository
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