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ProteomicsSpatial, Quantitative and Functional Deconstruction of Virus and Host Protein Interactions Inside Intact Cytomegalovirus Particles
Viral infections involve packaging of the viral genome and proteins into virions. Knowing virion composition and structure is critical to understand viral pathogenesis. However, an integrated picture of virion proteome organization of large viruses, such as Herpesviruses, is lacking. Here we use cro...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus Human betaherpesvirus 5 
2023-06-14 | PXD031911 | Pride
Cross-linking Virion Herpesvirus 
ProteomicsAssembly of cellular proteins with the HIV-1 genome into viral particles regulate virus production and infectivity
The initial steps of the human immunodeficiency virus 1 (HIV-1) lifecycle are regulated by cellular RNA-binding proteins (RBPs). However, the scope of these early host-virus interactions remain largely uncharecterised. To fill this gap, we developed in virion RNA interactome capture (ivRIC) to profi...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2026-05-25 | PXD042829 | Pride
Hiv  rna  rna-binding protein  virus infection  virion  viral particle  rev  rna-interactome capture  pura  purb 
UnknownStochastic model of vesicular stomatitis virus replication reveals mutational effects on virion production.
Not available
S-EPMC10878530 | biostudies-literature
UnknownGlycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.
Not available
S-EPMC5526109 | biostudies-literature
UnknownA multiscale coarse-grained model of the SARS-CoV-2 virion.
Not available
S-EPMC7695975 | biostudies-literature
GenomicsUnbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci
Genome-wide association studies have identified over 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts ha...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-55634 | biostudies-arrayexpress
ModelsHeldt2012 - Influenza Virus Replication
Heldt2012 - Influenza Virus Replication The model describes the life cycle of influenza A virus in a mammalian cell including the following steps: attachment of parental virions to the cell membrane, receptor-mediated endocytosis, fusion of the virus envelope with the endosomal mem...
2024-09-02 | BIOMD0000000463 | BioModels
GenomicsVirION - Towards Long Read viral Metagenomics
Using MinION sequencing to resolve issues of microdiversity and capture of phage genomic islands in marine viromes
PRJEB27181 | ENA
Genomics4C and Capture-C in HCT116, NCM460 cells and colon tissue
One of the strongest associated type 2 diabetes (T2D) loci reported to date resides within the TCF7L2 gene. Previous studies point to the T allele of rs7903146 in intron 3 as the causal variant at this locus. To aid in the identification of the actual gene(s) under the influence of this variant, we ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-MTAB-4845 | biostudies-arrayexpress
UnknownThe human cytomegalovirus virion possesses an activated casein kinase II that allows for the rapid phosphorylation of the inhibitor of NF-kappaB, IkappaBalpha.
Not available
S-EPMC1900216 | biostudies-literature
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