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ProteomicsProteasome dysfunction leads to enhanced autophagy mediated degradation of mutant lamin A/C
Lamin A/C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamin A/C cause a heterogenous group of inherited degenerative diseases known as laminopathies. Previous studies have revealed...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD033937 | Pride
Lamin a/c Autophagy Ubiquitin-proteasome-system Disease mutations Degradation Ubiquitin 
TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
TranscriptomicsComprehensive Characterization of 3D Models for Prostate Cancer Growth and Invasion in Laminin-rich Extracellular Matrix
Full title: Comprehensive Characterization of Three-Dimensional Models for Prostate Cancer Growth and Invasion in Laminin-rich Extracellular Matrix Prostate Cancer (PrCa) cells undergo acinar morphogenesis and spheroid formation in three-dimensional (3D) culture, supported by laminin-rich extracellu...
ORGANISM(S): Homo sapiens 
2010-12-06 | E-GEOD-19426 | biostudies-arrayexpress
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