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TranscriptomicsAffect of antiviral ribavirin on YFV WT and vaccine strains.
Live-attenuated viral vaccines have been successfully used to combat infectious disease for decades but due to their empirical derivation, little is known about their mechanisms of attenuation. This lack of understanding makes the development of next generation live attenuated vaccines difficult. Th...
ORGANISM(S): Yellow fever virus 
2020-01-01 | E-MTAB-8504 | biostudies-arrayexpress
ProteomicsInteractome of the influenza A virus transcription/replication machinery
Analyses of AP-MS experiments performed in HEK 293T cells infected with the influenza A/WSN/33 virus. In half of the experiments the virus was modified to contain a C-terminal Strep tag on the polymerase subunit PB2. Full details in York et al. 'Interactome analysis of the influenza A virus transcr...
ORGANISM(S): Influenza A Virus Homo Sapiens (ncbitaxon:9606) 
2014-06-16 | MSV000078741 | MassIVE
TranscriptomicsGenetic analysis of a Zika Virus Envelope Glycosylation and Non-structural protein 4B P36 Double Mutant
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Live attenuated vaccines have been successfully used to combat infection by flaviviruses, such as yellow fever and Japanese encephalitis viruses. A Zika virus harboring combined mutations in the envelope...
ORGANISM(S): Zika virus 
2021-12-31 | E-MTAB-9496 | biostudies-arrayexpress
TranscriptomicsHost responses contributing to the attenuation of severe acute respiratory syndrome coronaviruses missing E protein domains
Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory disease leading to death in 10% of the infected people. A mouse adapted SARS-CoV lacking the envelope (E) protein (rSARS-CoV-MA15-?E) is attenuated in vivo. To identify E protein domains and host responses that contribute ...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-59185 | biostudies-arrayexpress
TranscriptomicsCharacterization of mutations in West Nile virus NS4B protein identifies proline residue 54 as a determinant of attenuation
The flavivirus genus has conserved NS4B residues at P54, L56, and W103. We sought to determine both in vitro and in vivo which mutations displayed attenuated characteristics for use as potential vaccine candidates.
ORGANISM(S): Yellow fever virus 
2023-10-06 | E-MTAB-9408 | biostudies-arrayexpress
UnknownExploratory re-encoding of yellow fever virus genome: new insights for the design of live-attenuated viruses.
Not available
S-EPMC6057501 | biostudies-literature
TranscriptomicsStructural and non-structural genes contribute to the genetic diversity of RNA viruses
With the advent of advanced sequencing technology, studies of RNA viruses have shown that genetic diversity contribute to both attenuation and virulence. The differences in genetic diversity of wild-type Asibi virus and 17D-204 vaccine provides an unique opportunity to investigate RNA population th...
ORGANISM(S): Yellow fever virus 
2018-10-16 | E-MTAB-6614 | biostudies-arrayexpress
GenomicsAttenuation of the M gene in Vesicular Stomatitis Virus Vector
Attenuation of the M gene in Vesicular Stomatitis Virus Vector
PRJNA1259969 | ENA
TranscriptomicsDifferentially-expressed miRNAs in MDBK cells infected with bovine viral diarrhea virus compared to MDBK cells
Non-canonical microRNAs (miRNAs) are a class of short endogenous RNA molecules with the ability to control development, autophagy, apoptosis and the stress response in eukaryotes by pairing with partially complementary sites in the 3' untranslated regions (UTRs) of targeted genes. Recent studies hav...
ORGANISM(S): Bos taurus 
2014-12-16 | E-GEOD-61251 | biostudies-arrayexpress
TranscriptomicsSevere acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress respo...
ORGANISM(S): Chlorocebus aethiops 
2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress
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