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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
ProteomicsChemical Proteomics Tracks Virus Entry and Uncovers NCAM1 As Zika Virus Receptor
We present a time-resolved chemical proteomic strategy to track the early-stage entry of ZIKV into host cells. ZIKV was labeled on its surface with a chemical probe, which carries a photocrosslinker to covalently link virus-interacting proteins in living cells on UV exposure at different time points...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2020-09-11 | PXD020119 | Pride
Proteomics zika virus 
ProteomicsGPI-Anchored Ligand-BioID2-Tagging System Identifies proteins Mediating Zika Virus Entry
Identification of host factors facilitating pathogen entry is critical for preventing infectious diseases. Here, we report a tagging system consisting of a viral receptor-binding protein (RBP) linked to BioID2, which is expressed on the cell surface via a GPI anchor. Using VSV or Zika virus (ZIKV) R...
ORGANISM(S): Homo Sapiens 
2022-10-12 | PXD037307 |
ProteomicsStructural Syntax of the Vaccinia Virus Entry-Fusion Complex
Mass spectrometry crosslinking and single-ended crosslinker aduct data was used to validate predictive models of the vaccinia virus entry-fusion complex.
ORGANISM(S): Vaccinia virus 
2026-05-29 | PXD077210 | Pride
Entry-fusion complex Crosslinking mass spectrometry Alphafold Vaccinia virus 
ProteomicsCD46 regulates hepatitis B virus entry by modulating cell-surface NTCP levels through cis-interaction
Hepatitis B virus (HBV) infection remains a major global health challenge. While sodium taurocholate co-transporting polypeptide (NTCP) is the primary receptor for HBV entry, the molecular mechanisms regulating NTCP-mediated viral entry remain incompletely understood. Here, we identified CD46 as a c...
ORGANISM(S): Homo Sapiens (human) 
2026-01-13 | PXD065037 | JPOST Repository
TranscriptomicsMouse Dendritic and Antigen Presenting Cell RTM-BM-2 Profiler PCR
Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various DC-specific genes. Mouse bone marrow Flt3L-derived dendritic cells were infected with chimeric H...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-24959 | biostudies-arrayexpress
TranscriptomicsMouse Interferon M-NM-1, M-NM-2 RTM-BM-2 Profiler PCR
Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various interferon-stimulated genes. Mouse bone marrow Flt3L-derived dendritic cells were infected with ...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-24957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken tracheal cells grown in vitro and infected with influenza virus compared to trachea from in vivo infected animals
Investigation whether tracheal organ cultures (TOCs) are a suitable model for characterization of early immune response triggered by influenza virus infection in the respiratory tract. Comparison to in vivo infected animals.
ORGANISM(S): Gallus gallus 
2009-07-31 | E-MTAB-12 | biostudies-arrayexpress
GenomicsVirus Entry is a Major Determinant of HCMV Latency in Monocytes
Virus Entry is a Major Determinant of HCMV Latency in Monocytes
PRJNA1179887 | ENA
ProteomicsAnalysis of proteins proximal to epsin 1 in A549 cells during entry of influenza A virus
Influenza A viruses (IAVs) are respiratory pathogens that represent a global concern due to their ability to cause seasonal epidemics and sporadic pandemics in the human population. Thus, a comprehensive understanding of IAV biology is essential in order to design effective antivirals. It is well es...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2025-05-08 | PXD058908 | Pride
Epsin 1 Proximity labelling Virus entry Turboid Influenza a virus 
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