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ProteomicsComprehensive proteomic characterization identifies potential molecular targets for therapy and imaging in the Cluster 1 human pheochromocytoma and paraganglioma
In order to identify new proteins with a potential to become targets for therapy or tumor imaging in pheochromocytoma and paraganglioma, we performed detailed proteomic analysis of 22 well-characterized human PPGL samples and normal chromaffin tissue from adrenal medulla. A standard quantitative pro...
ORGANISM(S): Homo sapiens (Human) 
2023-09-25 | PXD039788 | Pride
Surface proteins Pheochromocytoma Paraganglioma Pitchfork strategy Membrane proteome Human 
ProteomicsDeep membrane proteome profiling of high-risk human paraganglioma
We combined glycopeptide enrichment by N-glyco-FASP (Zielinska et al., 2010), SPEG (Tian et al., 2007) with a hydrophobic segment-oriented hpTC method (Vít et al 2016) and a standard “detergent and trypsin” approach into a tree-pronged “Pitchfork” strategy for the analysis of membrane proteome in hi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD029344 | Pride
Lc-msms Paraganglioma Membrane proteome Human Pitchfork strategy 
ProteomicsMultiomics approach to decipher pathophysiological mechanisms and therapeutic impact of methionine restriction in cystathionine β-synthase deficient homocystinuria
Background. Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, and a limited knowledge about underlying pathophysiological processes. Here we aimed at getting an in-depth insight into d...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD049417 | Pride
Cystathionine beta-synthase  homocystinuria  methionine restriction  metabolomics  proteomics 
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