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TranscriptomicsEffects of vitamin B12 on the gene expression of PAO1 under anaerobic growth conditions
Pseudomonas aeruginosa undergoes cell elongation and forms robust biofilms during anaerobic respiratory growth using nitrate (NO3-) as an alternative electron acceptor. Understanding the mechanism of cell shape change induced upon anaerobiosis is crucial to the development of effective treatments ag...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-06-17 | E-GEOD-34836 | biostudies-arrayexpress
MetabolomicsInsights into the stereochemical mechanism of the B12-dependent radical SAM glutamine C- methyltransferases QCMT
Methyl-coenzyme M reductase (MCR) is a crucial enzyme for methanogenesis and harbors several unusual post-translational modifications. Recent studies have identified glutamine C-methyltransferase (QCMT), as a B12-dependent radical SAM enzyme responsible for methylating a glutamine residue within the...
2026-04-28 | MTBLS14287 | MetaboLights
TranscriptomicsEffect of amino acid availability on vitamin B12 production in Lactobacillus reuteri
Recent functional genomics and genome-scale modeling approaches indicated that B12 production in Lactobacillus reuteri could be improved by medium optimization. Here we show that a series of systematic single amino acid omissions could significantly modulate the production of B12 from nearly undetec...
ORGANISM(S): Lactobacillus reuteri F275 
2010-05-17 | E-GEOD-13391 | biostudies-arrayexpress
TranscriptomicsFolate and vitamin B12 imbalance induces endoplasmic reticulum stress and cholesterol biosynthesis gene expression in human adipocytes
Rationale: Low B12 has been shown to play an important role in the prediction of metabolic risk, but its significance and mechanism in the development of adiposity and adipose tissue dysfunction is largely unknown. Objective: To investigate the role of B12 and folic acid in the development of adipo...
ORGANISM(S): Homo sapiens 
2012-12-30 | E-GEOD-43166 | biostudies-arrayexpress
ProteomicsProteomic Analysis Reveals the Mechanisms Underlying Ischemic Stroke Induced by Vitamin B12 Deficiency
Recruit patients with first-ever acute ischemic stroke (AIS) and classify them into two study groups based on the presence or absence of vitamin B12 deficiency, while also including a matched healthy control group. Utilize 4D-DIA proteomics technology to analyze the protein expression profiles and i...
ORGANISM(S): Homo sapiens (Human) 
2026-02-20 | PXD062264 | Pride
Vitamin b12 deficiency Proteomic Ischemic stroke 
ProteomicsNew Roles for Vitamin B12 Regulation
Elucidation of new roles for vitamin B12 in regulation of folate, ubiquinone, and methionine metabolism
ORGANISM(S): Halomonas sp. HL-48 environmental samples 
2018-10-22 | PXD005723 | Pride
Abp Proteomics B12 
TranscriptomicsMicroarray analysis of liver and mammary gland biopsies of dairy cows supplemented with vitamins B9 and B12 alone or in combination
Data from one animal from B9_B12 group (Cow 31) were not taken into account for the liver samples Treated animals were compared to control (non supplemented cows) Twenty four multiparous Holstein cows were assigned to 6 blocks of 4 animals according to their 305-d milk production during the previou...
ORGANISM(S): Bos taurus 
2016-06-30 | E-GEOD-77421 | biostudies-arrayexpress
TranscriptomicsEffects of Intramuscular Administration of Folic Acid and Vitamin B12 on Granulosa Cells Gene Expression in Postpartum Dairy Cow
The fertility of dairy cows is challenged during early lactation and better nutritional strategies need to be developed to address this issue. Combined supplementation of folic acid and vitamin B12 improves energy metabolism in the dairy cow during early lactation. Therefore, the present study was u...
ORGANISM(S): Bos taurus 
2015-09-15 | E-GEOD-72038 | biostudies-arrayexpress
TranscriptomicsPocR regulates glycerol reduction, assembly of metabolosomes and vitamin B12 biosynthesis in Lactobacillus reuteri F275
Lactobacillus reuteri has been shown to encode a vitamin B12 biosynthesis pathway that is phylogenetically related to the one present in some representatives of gamma-proteobacteria such as Salmonella and Yersinia. Here we present evidence supporting that the similarities between these otherwise unr...
ORGANISM(S): Lactobacillus reuteri F275 
2010-05-17 | E-GEOD-13289 | biostudies-arrayexpress
GenomicsTransthyretin orchestrates vitamin B12-induced stress resilience
Transthyretin orchestrates vitamin B12-induced stress resilience
PRJNA1109405 | ENA
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