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MetabolomicsVitamin B6 Effects on one-carbon metabolism
Not available
ORGANISM(S): Homo sapiens 
ST000293 | MetabolomicsWorkbench
MetabolomicsExploiting Vitamin B6 Dependency: BVL3572S Inhibits HisC and AlaA to Kill Mycobacterium tuberculosis

Tuberculosis remains the leading cause of death from a single infectious agent worldwide, and the growing prevalence of multi-drug resistant Mycobacterium tuberculosis (Mtb) underscores the urgent need for antibiotics with novel mechanisms of action. Here, we characterize BVL3572S, a hydroxamic a...

2026-06-23 | MTBLS14782 | MetaboLights
TranscriptomicsVitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
Hippocampal apoptosis is a characteristic feature of penumococcal meningitis associated with learning and memory deficitis as a sequel of the disease. We investigated the effect of vitamin B6 using an established infant rat model of experimental pneumococcal meningitis by histomorphology, transcript...
ORGANISM(S): Rattus norvegicus 
2012-02-20 | E-MEXP-3555 | biostudies-arrayexpress
TranscriptomicsExpression data from WT Col-0 and the pdx1.3 ko mutant of Arabidopsis
We performed a microarray experiment to assess the global changes in transcription occurring in leaves and roots of the vitamin B6 deficient pdx1.3 knockout mutant in comparison to WT. Vitamin B6 (pyridoxal 5′-phosphate) is an essential cofactor of many metabolic enzymes. Plants biosynthesize the vi...
ORGANISM(S): Arabidopsis thaliana 
2015-07-25 | E-GEOD-71312 | biostudies-arrayexpress
MetabolomicsTC and B6 untreated plasma in lupus-prone mice lipidomics (part-II)
Not available
ORGANISM(S): Mus musculus 
ST000310 | MetabolomicsWorkbench
ProteomicsVitamin B6 form produced by Lactobacillus induces metabolic disorder and suppresses multi-pathogenic bacteria
Vitamin B6 comprises six vitamers, pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5′-phosphate (PLP), pyridoxine 5′-phosphate (PNP), and pyridoxamine 5′-phosphate (PMP), recognized for pleiotropic functions in mitigating oxidative stress and modulating metabolic homeostasis. This study reveals that...
ORGANISM(S): Carassius 
2026-01-26 | PXD070947 | Pride
Probiotic consortium Pyridoxamine 5'-phosphate Metabolism Pathogens Vitamin b6 Gut microbiome 
GenomicsVitamin B6 metabolism determines T cell anti-tumor responses
Vitamin B6 metabolism determines T cell anti-tumor responses
PRJNA758697 | ENA
TranscriptomicsIdentification of candidate susceptibility and resistance genes of mice infected with Streptococcus suis type 2
There were four groups:control A/J mice;control B6 mice;SS2-infected A/J mice;SS2-infected B6 mice.The RNA samples of four groups were sent to Biostar Genechip Inc. (Shanghai, China) for microarray hybridization. The pooled RNA sample from each group was hybridized to one Illumina mouse Genome Beadc...
ORGANISM(S): Mus Musculus 
2012-02-09 | E-MTAB-745 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression profiling of aortic genes of APOE-deficient mice receiving atherosclerosis treatment with the antioxidant vitamin E
Hypercholesterolemic APOE-deficient mice are a widely used experimental model of atherosclerosis and increased generation of reactive oxygen species (ROS) is a prominent feature of atherosclerosis development. To study the impact of ROS on atherogenesis, we treated APOE-deficient mice for 7 months w...
ORGANISM(S): Mus musculus 
2012-12-11 | E-GEOD-42813 | biostudies-arrayexpress
ProteomicsCoculture of Collinsella aerofaciens and Bacteroides thetaiotaomicron under bile acid stress reveals vitamin B6 exchange
Background: Although the bile acid-mediated microbiome-host interaction is known to shape both the composition and functionality of the gut microbiome, the mechanisms by which bile acid stress influences specific microbial metabolic interactions remain poorly understood. To address this gap, we exam...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Collinsella aerofaciens ATCC 25986 
2026-01-06 | PXD069395 | Pride
Branched-chain amino acid Vitamin b6 Collinsella aerofaciens Gut-liver axis Deoxycholic acid Bacteroides thetaiotaomicron Cross-feeding Bile acids Pyridoxal 5’-phosphate Arginine metabolism 
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