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UnknownCOVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses.
Not available
S-EPMC7871825 | biostudies-literature
ProteomicsMoyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
RNF213 is the major susceptibility factor for Moyamoya disease, a progressive cerebrovascular disorder that often leads to brain stroke in adults and children. Characterization of disease-associated mutations has been complicated by the enormous size of RNF213. Here we present the cryo-EM structure ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-24 | PXD018701 | Pride
Rnf213 Mouse E3-ligase 
TranscriptomicsSpecific and pleiotropic patterns of mRNA regulation by ArcZ
The small RNA, ArcZ (previously RyhA/SraH), was discovered in several genome-wide screens in Escherichia coli and Salmonella. Its high degree of genomic conservation, its frequent recovery by shotgun sequencing, and its association with the RNA chaperone, Hfq, identified ArcZ as an abundant enteroba...
ORGANISM(S): Salmonella enterica 
2009-10-19 | E-GEOD-17771 | biostudies-arrayexpress
ProteomicsUNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Myosin motors are critical for diverse motility functions ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub ...
ORGANISM(S): Caenorhabditis elegans 
2024-07-25 | PXD040428 | Pride
Ufd-2 Myopathy Mhc-b Myo4 Protein quality control Crosslinking mass spectrometry Ubiquitin proteasome system Unc-45 Molecular chaperones Myosin proteostasis 
TranscriptomicsThe Histone H2B Monoubiquitination Regulatory Pathway is Required for Differentiation of Multipotent Stem Cells
Extensive changes in post-translational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their function during differentiation remain only poorly under...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-38173 | biostudies-arrayexpress
UnknownCryo-EM structure of RNF213 reveals a RING-type E3 with a dynein core and cysteine reactivity
Not available
EMPIAR-10334 | biostudies-other
TranscriptomicsGENCODE Batch VIII b: determining lncRNA transcript 5' and 3'-ends by RACE-PCR / 454 sequencing
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. In the current phase of ENCODE we have found strong evidence that many lncRNAs transcript termini are still unknown. This experiment aims to set up an experimental val...
ORGANISM(S): Homo sapiens 
2012-08-31 | E-MTAB-1226 | biostudies-arrayexpress
TranscriptomicsGENCODE PCR-Seq Batch X
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. Selected transcript models are verified experimentally by RT-PCR amplification of at least one of their unique splice junctions followed by sequencing. Batch X targets...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-1310 | biostudies-arrayexpress
TranscriptomicsGENCODE PCR-Seq Batch IX
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. Selected transcript models are verified experimentally by RT-PCR amplification followed by sequencing. In batch IX, a set of de novo transcript models was tested aimin...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-MTAB-1309 | biostudies-arrayexpress
TranscriptomicsGENCODE PCR-Seq Batch XI
As part of the ENCODE consortium the GENCODE project is producing a reference gene set through manual and automated gene prediction. Selected transcript models are verified experimentally by RT-PCR amplification of at least one of their unique splice junctions followed by sequencing. The experiment ...
ORGANISM(S): Homo sapiens 
2013-02-19 | E-MTAB-1505 | biostudies-arrayexpress
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